Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 19/20 | 0.74 |
| ▸ | FXR2 | P51116 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17145988 | 0.93 | NR1H4 (0.84) | NR1H4FXR2 | |
| SCHEMBL17848232 | 0.93 | NR1H4 (0.84) | NR1H4FXR2 | |
| SCHEMBL10263154 | 0.93 | NR1H4 (0.84) | NR1H4FXR2 | |
| SCHEMBL20833906 | 0.93 | NR1H4 (0.85) | NR1H4FXR2 | |
| SCHEMBL20833909 | 0.93 | NR1H4 (0.85) | NR1H4FXR2 | |
| SCHEMBL19189876 | 0.92 | NR1H4 (0.69) | NR1H4FXR2 | |
| SCHEMBL20833813 | 0.92 | NR1H4 (0.69) | NR1H4FXR2 | |
| SCHEMBL20833907 | 0.91 | NR1H4 (0.74) | NR1H4FXR2 | |
| SCHEMBL20833695 | 0.89 | NR1H4 (0.73) | NR1H4FXR2 | |
| SCHEMBL9955743 | 0.89 | NR1H4 (0.81) | NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190083473-A1 | AZABICYCLOOCTANE DERIVATIVES AS FXR AGONISTS FOR USE IN THE TREATMENT OF LIVER AND GASTROINTESTINAL DISEASES | NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC., DBA GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION (GNF) | 2019-03-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190083473-A1 | AZABICYCLOOCTANE DERIVATIVES AS FXR AGONISTS FOR USE IN THE TREATMENT OF LIVER AND GASTROINTESTINAL DISEASES | NR1H4, FXR1, FXR2 | NR1H4 1/4885FXR2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.