Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 2/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848137 | 0.92 | MAPK1 (0.37) | MAPK1MKNK1MKNK2CDC7AURKA | |
| SCHEMBL17848411 | 0.85 | MPO (0.37) | MAPK1MPOJAK2JAK3PRKAA1 | |
| SCHEMBL20560052 | 0.85 | SGK1 (0.39) | MAPK1MPOJAK2CSF1RJAK3 | |
| SCHEMBL20560056 | 0.85 | MKNK1 (0.47) | MAPK1MKNK1MKNK2MPOHCAR2 | |
| SCHEMBL20559532 | 0.83 | JAK2 (0.37) | MAPK1MKNK1MKNK2CDC7AURKA | |
| SCHEMBL17848111 | 0.82 | MAPK1 (0.43) | MAPK1CDC7AURKADAPK3JAK2 | |
| SCHEMBL20559448 | 0.81 | MAP2K4 (0.37) | MAPK1HSP90AB1CDC7AURKADAPK3 | |
| SCHEMBL20560066 | 0.77 | JAK2 (0.39) | MAPK1CDC7AURKADAPK3JAK2 | |
| SCHEMBL17848143 | 0.76 | FGFR1 (0.43) | MKNK1MKNK2HSP90AB1DAPK3JAK2 | |
| SCHEMBL17848108 | 0.75 | MAPK1 (0.47) | MAPK1MKNK1MKNK2MPOHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233840-B1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S R L (IT) | 2018-11-21 | — | — | EP | claimed |
| EP-3233840-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | Eudendron S.r.l. (IT) | 2017-10-25 | — | — | EP | claimed |
| WO-2016096709-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S.R.L. (IT) | 2016-06-23 | — | — | WO | claimed |