Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 17/20 | 0.82 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848503 | 1.00 | DRD2 (0.82) | DRD2LTA4HBACE1LMNAMAPK1 | |
| SCHEMBL17848461 | 0.90 | DRD2 (1.00) | DRD2 | |
| SCHEMBL17848620 | 0.89 | DRD2 (0.81) | DRD2LMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL17848539 | 0.87 | DRD2 (0.78) | DRD2LMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL17848389 | 0.87 | DRD2 (0.78) | DRD2LMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL17848580 | 0.86 | DRD2 (0.76) | DRD2LMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL17848387 | 0.86 | DRD2 (0.79) | DRD2 | |
| SCHEMBL17848385 | 0.85 | DRD2 (0.90) | DRD2LTA4H | |
| SCHEMBL17848590 | 0.85 | DRD2 (0.89) | DRD2 | |
| SCHEMBL17848567 | 0.84 | DRD2 (0.77) | DRD2LTA4HLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233077-A1 | DOPAMINE D2 RECEPTOR LIGANDS | The Broad Institute Inc. (US) | 2017-10-25 | — | — | EP | claimed |
| WO-2016100940-A1 | DOPAMINE D2 RECEPTOR LIGANDS | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | claimed |
| EP-3233077-A1 | DOPAMINE D2 RECEPTOR LIGANDS | The Broad Institute Inc. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100940-A1 | DOPAMINE D2 RECEPTOR LIGANDS | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |