Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 16/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848643 | 0.94 | DRD2 (0.66) | DRD2DRD3DRD4 | |
| SCHEMBL29944218 | 0.94 | DRD2 (0.66) | DRD2DRD3DRD4 | |
| SCHEMBL17848387 | 0.85 | DRD2 (0.79) | DRD2DRD3 | |
| SCHEMBL17848385 | 0.82 | DRD2 (0.90) | DRD2 | |
| SCHEMBL17848724 | 0.80 | DRD2 (0.66) | DRD2 | |
| SCHEMBL17848628 | 0.80 | DRD2 (0.75) | DRD2 | |
| SCHEMBL17848652 | 0.80 | DRD2 (0.64) | DRD2 | |
| SCHEMBL17848620 | 0.79 | DRD2 (0.81) | DRD2 | |
| SCHEMBL17848461 | 0.78 | DRD2 (1.00) | DRD2 | |
| SCHEMBL17848575 | 0.78 | DRD2 (0.82) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233077-A1 | DOPAMINE D2 RECEPTOR LIGANDS | The Broad Institute Inc. (US) | 2017-10-25 | — | — | EP | claimed |
| WO-2016100940-A1 | DOPAMINE D2 RECEPTOR LIGANDS | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | claimed |
| EP-3233077-A1 | DOPAMINE D2 RECEPTOR LIGANDS | The Broad Institute Inc. (US) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016100940-A1 | DOPAMINE D2 RECEPTOR LIGANDS | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |