Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 15/20 | 0.67 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17848517 | 0.80 | DRD2 (1.00) | DRD2 | |
| SCHEMBL17848732 | 0.79 | DRD2 (0.67) | DRD2CCR1OPRM1OPRL1HSD11B1 | |
| SCHEMBL17848679 | 0.79 | DRD2 (0.67) | DRD2CCR1HSD11B1HSD11B2 | |
| SCHEMBL17848767 | 0.79 | DRD2 (0.67) | DRD2CCR1HTR1AOPRM1HSD11B1 | |
| SCHEMBL21908465 | 0.79 | DRD2 (0.60) | DRD2CCR1HTR1AOPRM1HSD11B1 | |
| SCHEMBL17848686 | 0.78 | DRD2 (0.64) | DRD2CCR1 | |
| SCHEMBL17848738 | 0.77 | DRD2 (0.71) | DRD2 | |
| SCHEMBL17848656 | 0.76 | DRD2 (0.63) | DRD2CCR1HSD11B1HSD11B2 | |
| SCHEMBL17848749 | 0.76 | DRD2 (0.73) | DRD2 | |
| SCHEMBL17848710 | 0.75 | DRD2 (0.60) | DRD2CCR1HTR1AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233077-A1 | DOPAMINE D2 RECEPTOR LIGANDS | The Broad Institute Inc. (US) | 2017-10-25 | — | — | EP | claimed |
| WO-2016100940-A1 | DOPAMINE D2 RECEPTOR LIGANDS | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | claimed |