Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 15/20 | 0.74 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2B | P41595 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17861613 | 0.92 | DRD2 (0.75) | DRD2HTR2AHTR2BDRD3HTR1A | |
| SCHEMBL17848324 | 0.89 | DRD2 (0.76) | DRD2HTR2AHTR2BDRD3HTR1A | |
| SCHEMBL17848400 | 0.89 | DRD2 (0.76) | DRD2HTR2AHTR2BDRD3HTR1A | |
| SCHEMBL17848696 | 0.85 | DRD2 (0.70) | DRD2HTR2AHTR2BDRD3HTR1A | |
| SCHEMBL17848402 | 0.85 | DRD2 (0.70) | DRD2HTR2AHTR2BDRD3HTR1A | |
| SCHEMBL17848610 | 0.85 | DRD2 (1.00) | DRD2HTR2AHTR2BDRD3HTR1A | |
| SCHEMBL17848421 | 0.84 | DRD2 (0.72) | DRD2HTR2AHTR2BDRD3HTR1A | |
| SCHEMBL17848497 | 0.84 | DRD2 (0.72) | DRD2HTR2AHTR2BDRD3HTR1A | |
| SCHEMBL17848480 | 0.84 | DRD2 (1.00) | DRD2HTR2AHTR2BDRD3HTR1A | |
| SCHEMBL17848380 | 0.84 | DRD2 (0.80) | DRD2HTR2AHTR2BDRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233077-A1 | DOPAMINE D2 RECEPTOR LIGANDS | The Broad Institute Inc. (US) | 2017-10-25 | — | — | EP | claimed |
| WO-2016100940-A1 | DOPAMINE D2 RECEPTOR LIGANDS | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | claimed |