Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | STK4 | Q13043 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3313799 | 0.92 | TYK2 (0.40) | TYK2PDE4DGRM4HIPK2CDK2 | |
| SCHEMBL2358576 | 0.92 | TYK2 (0.37) | TYK2PDE4DGRM4MEN1KMT2A | |
| SCHEMBL3311950 | 0.88 | DYRK3 (0.46) | TYK2PDE4DCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL2357817 | 0.84 | TYK2 (0.38) | TYK2PDE4DGRM4HIPK2CDK2 | |
| SCHEMBL3315482 | 0.84 | CSNK2A1 (0.49) | TYK2KCNH2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL2358223 | 0.79 | TYK2 (0.38) | TYK2KCNH2PDE4DCSNK2A2CSNK2B | |
| SCHEMBL3317123 | 0.79 | TYK2 (0.46) | TYK2KCNH2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL13421523 | 0.79 | TYK2 (0.40) | TYK2PDE4DGRM4MEN1KMT2A | |
| SCHEMBL2356820 | 0.79 | CSNK2A2 (0.46) | TYK2KCNH2PDE4DCSNK2A2CSNK2B | |
| SCHEMBL2358706 | 0.78 | TYK2 (0.51) | TYK2PDE4DCSNK2A2CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9371328-B2 | Imidazopyridazinecarbonitriles useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-06-21 | — | — | US | disclosed |
| US-9371328-B2 | Imidazopyridazinecarbonitriles useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-06-21 | — | — | US | disclosed |