Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 14/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3313799 | 0.85 | TYK2 (0.40) | TYK2PDE4DGRM4STAT3AURKA | |
| SCHEMBL2359440 | 0.85 | TYK2 (0.48) | TYK2STAT3CDK2GSK3BHIPK2 | |
| SCHEMBL17849713 | 0.84 | TYK2 (0.38) | TYK2PDE4DGRM4CDK2GSK3B | |
| SCHEMBL2358576 | 0.83 | TYK2 (0.37) | TYK2PDE4DGRM4 | |
| SCHEMBL3311950 | 0.79 | DYRK3 (0.46) | TYK2PDE4DAURKACDK2AURKB | |
| SCHEMBL2358223 | 0.78 | TYK2 (0.38) | TYK2PDE4DCDK2GSK3BHIPK2 | |
| SCHEMBL3311783 | 0.76 | TYK2 (0.39) | TYK2PDE4DSTAT3 | |
| SCHEMBL2359458 | 0.75 | TYK2 (0.49) | TYK2PDE4DSTAT3CDK2GSK3B | |
| SCHEMBL2357715 | 0.74 | TYK2 (0.44) | TYK2STAT3 | |
| SCHEMBL2358275 | 0.74 | TYK2 (0.35) | TYK2PDE4DCDK2MAPK8GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350081-A1 | IMIDAZOPYRIDAZINECARBONITRILES USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2011-08-03 | — | — | EP | disclosed |