Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL105885 | 0.84 | HSP90AA1 (0.59) | HSP90AA1POLBTDP1GAARAB9A | |
| SCHEMBL110210 | 0.79 | HSP90AA1 (0.59) | HSP90AA1POLBTDP1GAARAB9A | |
| SCHEMBL108658 | 0.77 | HSP90AA1 (0.56) | HSP90AA1POLBTDP1GAARAB9A | |
| SCHEMBL108507 | 0.76 | HSP90AA1 (0.52) | HSP90AA1POLBTDP1GAARAB9A | |
| SCHEMBL109090 | 0.76 | HSP90AA1 (0.52) | HSP90AA1POLBTDP1GAARAB9A | |
| SCHEMBL109791 | 0.75 | HSP90AA1 (0.57) | HSP90AA1POLBTDP1GAARAB9A | |
| SCHEMBL105677 | 0.75 | HSP90AA1 (0.57) | HSP90AA1POLBTDP1GAARAB9A | |
| SCHEMBL109098 | 0.75 | HSP90AA1 (0.64) | HSP90AA1POLBTDP1GAARAB9A | |
| SCHEMBL107345 | 0.74 | RXFP1 (0.66) | HSP90AA1POLBGAARAB9ASMN1; SMN2 | |
| SCHEMBL108738 | 0.73 | P2RX7 (0.62) | HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424869-B1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LTD (GB) | 2016-06-22 | — | — | EP | disclosed |