Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17850363 | 0.91 | MAPK14 (0.44) | ATMP2RX7ROCK2ROCK1KLKB1 | |
| SCHEMBL17850355 | 0.82 | ATM (0.45) | ATMP2RX7ROCK2ROCK1MET | |
| SCHEMBL17850365 | 0.81 | ATM (0.46) | ATMP2RX7ROCK2ROCK1MET | |
| SCHEMBL17850366 | 0.80 | ATM (0.45) | ATMP2RX7ROCK2ROCK1MET | |
| SCHEMBL22058715 | 0.80 | ATM (0.55) | ATMP2RX7ROCK2ROCK1SCN9A | |
| SCHEMBL13939305 | 0.78 | MEN1 (0.51) | SMN1; SMN2NPC1POLBRAB9A | |
| SCHEMBL6358893 | 0.76 | ATM (0.60) | ATMP2RX7ROCK2ROCK1SCN9A | |
| SCHEMBL6357149 | 0.75 | ATM (0.59) | ATMP2RX7ROCK2ROCK1SMN1; SMN2 | |
| SCHEMBL6362683 | 0.74 | ATM (0.55) | ATMP2RX7ROCK2ROCK1LMNA | |
| SCHEMBL6362518 | 0.74 | ATM (0.58) | ATMP2RX7ROCK2ROCK1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3034494-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | President and Fellows of Harvard College (US) | 2016-06-22 | — | — | EP | disclosed |