Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17850365 | 0.99 | ATM (0.46) | ATMP2RX7KMT2AGAAROCK2 | |
| SCHEMBL17850355 | 0.98 | ATM (0.45) | ATMP2RX7KMT2AGAAROCK2 | |
| SCHEMBL17850362 | 0.89 | P2RX7 (0.39) | ATMP2RX7KMT2A | |
| SCHEMBL17850360 | 0.84 | P2RX7 (0.43) | ATMP2RX7ROCK2ROCK1MET | |
| SCHEMBL17850367 | 0.83 | P2RX7 (0.45) | ATMP2RX7ROCK2ROCK1 | |
| SCHEMBL17850357 | 0.80 | ATM (0.56) | ATMP2RX7ROCK2ROCK1EPHX2 | |
| SCHEMBL17850358 | 0.79 | LMNA (0.58) | ATMKMT2AGAAALDH1A1MAPT | |
| SCHEMBL6356852 | 0.75 | P2RX7 (0.59) | ATMP2RX7KMT2AGAAEPHX2 | |
| SCHEMBL12852321 | 0.74 | ATM (0.66) | ATMP2RX7KMT2AGAAROCK2 | |
| SCHEMBL6362551 | 0.73 | P2RX7 (0.60) | ATMP2RX7KMT2AGAAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3034494-A1 | HETEROCYCLIC INHIBITORS OF NECROPTOSIS | President and Fellows of Harvard College (US) | 2016-06-22 | — | — | EP | disclosed |