Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1335714 | 1.00 | SLC6A4 (0.44) | SLC6A4SLC6A2SLC6A3SLC18A3MAPT | |
| SCHEMBL1335712 | 1.00 | SLC6A4 (0.44) | SLC6A4SLC6A2SLC6A3SLC18A3MAPT | |
| SCHEMBL9911019 | 0.79 | SLC6A4 (0.55) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL1206040 | 0.79 | SLC6A2 (0.54) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL1206038 | 0.79 | SLC6A2 (0.54) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL25230604 | 0.79 | ESR2 (0.50) | — | |
| SCHEMBL1335690 | 0.79 | SLC6A4 (0.42) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL1335693 | 0.79 | SLC6A4 (0.49) | SLC6A4SLC6A2SLC6A3HTR2C | |
| SCHEMBL1335696 | 0.79 | SLC6A4 (0.49) | SLC6A4SLC6A2SLC6A3HTR2C | |
| SCHEMBL2681419 | 0.79 | CHRNB2 (0.35) | SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350068-B1 | UREA DERIVATIVES OF SUBSTITUTED NORTROPANES, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE | BOEHRINGER INGELHEIM INT (DE) | 2017-08-30 | — | — | EP | disclosed |
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |
| EP-2318403-B1 | Aryl- and heteroarylcarbonyl derivatives of substituted nortropanes, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INT (DE) | 2015-12-23 | — | — | EP | disclosed |