Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.40 |
| ▸ | MAPK6 | Q16659 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | STK25 | O00506 | 1/20 | 0.40 |
| ▸ | CIT | O14578 | 1/20 | 0.40 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9953146 | 0.94 | POLB (0.42) | ROCK1ROCK2IRAK4FLT3MAP4K4 | |
| SCHEMBL10194885 | 0.91 | LRRK2 (0.43) | FGFR1FLT1MAPK10ITKLRRK2 | |
| SCHEMBL10194865 | 0.91 | MAPK10 (0.42) | ROCK1ROCK2IRAK4FLT3MAP4K4 | |
| SCHEMBL9952065 | 0.85 | CDC7 (0.46) | ROCK1ROCK2IRAK4FLT3MAP4K4 | |
| SCHEMBL9952277 | 0.84 | NPC1 (0.44) | ROCK2IRAK4FLT3MAP4K4HIPK2 | |
| SCHEMBL10194814 | 0.83 | ROCK1 (0.43) | ROCK1ROCK2CHEK1MAPK8MAPK10 | |
| SCHEMBL9951810 | 0.82 | FKBP1A (0.47) | FGFR1FLT1MAPK10ITKLRRK2 | |
| SCHEMBL10194847 | 0.80 | MAPT (0.47) | ROCK1ROCK2MAPK8FGFR1FLT1 | |
| SCHEMBL10194944 | 0.80 | MAPK10 (0.46) | ROCK1ROCK2FLT3CHEK1FGFR1 | |
| SCHEMBL9952518 | 0.80 | CDC7 (0.44) | ROCK1ROCK2IRAK4MAP4K4HIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |