Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 8/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10194694 | 0.88 | MET (0.42) | METJAK2MAPK10LRRK2KDM4E | |
| SCHEMBL10194761 | 0.84 | MET (0.39) | METJAK2MAPK10LRRK2KDM4E | |
| SCHEMBL9952385 | 0.80 | JAK2 (0.41) | METJAK2MAPK10LRRK2KDM4E | |
| SCHEMBL10194759 | 0.79 | JAK2 (0.40) | METJAK2MAPK10LRRK2KDM4E | |
| SCHEMBL10194788 | 0.79 | JAK2 (0.42) | METJAK2MAPK10LRRK2KDM4E | |
| SCHEMBL10196685 | 0.78 | MAPK10 (0.41) | METJAK2MAPK10LRRK2MAPT | |
| SCHEMBL10194734 | 0.77 | JAK2 (0.41) | METJAK2MAPK10LRRK2FLT3 | |
| SCHEMBL9952225 | 0.76 | GAA (0.44) | JAK2MAPK10LRRK2KDM4EALDH1A1 | |
| SCHEMBL9951714 | 0.74 | MET (0.41) | MET | |
| SCHEMBL9952483 | 0.72 | MAPK10 (0.45) | JAK2MAPK10LRRK2ALDH1A1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |