Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.49 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9928308 | 0.87 | ACHE (0.62) | KMT2AMEN1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL15317649 | 0.85 | MEN1 (0.58) | KMT2AMEN1ALDH1A1LMNAHPGD | |
| SCHEMBL10195735 | 0.83 | KMT2A (0.65) | KMT2AMEN1ALDH1A1LMNAHSD11B1 | |
| SCHEMBL18235883 | 0.82 | KMT2A (0.63) | KMT2AMEN1ALDH1A1LMNAHSD11B1 | |
| SCHEMBL21078088 | 0.81 | KMT2A (0.61) | KMT2AMEN1ALDH1A1LMNAHSD11B1 | |
| SCHEMBL10194845 | 0.81 | KMT2A (0.61) | KMT2AMEN1ALDH1A1LMNAHSD11B1 | |
| SCHEMBL10196662 | 0.80 | KMT2A (0.65) | KMT2AMEN1ALDH1A1LMNAHSD11B1 | |
| SCHEMBL23417126 | 0.79 | KMT2A (0.60) | KMT2AMEN1ALDH1A1LMNAHSD11B1 | |
| SCHEMBL18732487 | 0.79 | KMT2A (0.60) | KMT2AMEN1ALDH1A1LMNAHSD11B1 | |
| SCHEMBL10720760 | 0.79 | JAK1 (0.54) | KMT2AMEN1ALDH1A1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |