Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16893911 | 0.89 | PTGS2 (0.81) | PTGS2PTGS1 | |
| Tigemocoxib SCHEMBL30656557 | 0.89 | PTGS2 (1.00) | PTGS2PTGS1 | |
| Tigemocoxib SCHEMBL30656575 | 0.89 | PTGS2 (1.00) | PTGS2PTGS1 | |
| Tigemocoxib SCHEMBL2736424 | 0.89 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL16893912 | 0.89 | PTGS2 (0.81) | PTGS2PTGS1 | |
| Tigemocoxib SCHEMBL216759 | 0.89 | PTGS2 (1.00) | PTGS2PTGS1 | |
| SCHEMBL17858788 | 0.89 | PTGS2 (0.81) | PTGS2PTGS1 | |
| Tigemocoxib SCHEMBL5171872 | 0.89 | PTGS2 (1.00) | PTGS2PTGS1 | |
| Tigemocoxib SCHEMBL29528190 | 0.89 | PTGS2 (1.00) | PTGS2PTGS1 | |
| Tigemocoxib SCHEMBL15845456 | 0.88 | PTGS2 (0.97) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9452220-B2 | Coupling compounds of NSAID anti-inflammatory and analgesic drugs and EGFR kinase inhibitors, synthesis methods and applications thereof | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2016-09-27 | — | — | US | disclosed |
| US-20160175453-A1 | COUPLING COMPOUNDS OF NSAID ANTI-INFLAMMATORY AND ANALGESIC DRUGS AND EGFR KINASE INHIBITORS, SYNTHESIS METHODS AND APPLICATIONS THEREOF | GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH, CHINESE ACADEMY OF SCIENCES (CN) | 2016-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160175453-A1 | COUPLING COMPOUNDS OF NSAID ANTI-INFLAMMATORY AND ANALGESIC DRUGS AND EGFR KINASE INHIBITORS, SYNTHESIS METHODS AND APPLICATIONS THEREOF | EGFR, CHUK, ERBB2 | PTGS2 9/4885PTGS1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.