Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | COMT | P21964 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.39 |
| ▸ | AHR | P35869 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3921056 | 0.81 | DYRK1A (0.58) | DYRK1ACOMTPDE10AAHRALDH1A1 | |
| SCHEMBL477109 | 0.76 | DYRK1A (0.53) | DYRK1ACOMTPDE10AAHRALDH1A1 | |
| SCHEMBL1054695 | 0.76 | DYRK1A (0.53) | DYRK1ACOMTPDE10AAHRALDH1A1 | |
| SCHEMBL17232819 | 0.76 | DYRK1A (0.53) | DYRK1ACOMTPDE10AAHRALDH1A1 | |
| SCHEMBL29020764 | 0.76 | DYRK1A (0.53) | DYRK1ACOMTPDE10AAHRALDH1A1 | |
| SCHEMBL25104909 | 0.76 | DYRK1A (0.41) | DYRK1ACOMTPDE10AAHRALDH1A1 | |
| SCHEMBL2514258 | 0.76 | PIK3CG (0.40) | DYRK1AAHRAKT1PIK3CAPIK3CD | |
| SCHEMBL13862032 | 0.76 | PIK3CG (0.32) | DYRK1AAHRPIK3CAPIK3CG | |
| Hydrochloric Acid SCHEMBL252835 | 0.74 | PIK3CG (0.39) | DYRK1AAHRAKT1PIK3CAPIK3CG | |
| SCHEMBL2067022 | 0.73 | DYRK1A (0.50) | DYRK1ACOMTPDE10AAHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230312585-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2023-10-05 | — | — | US | disclosed |
| WO-2016097347-A1 | IMIDAZOPYRIDAZINE DERIVATIVES AS ΡΙ3Κβ INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230312585-A1 | SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE | HRH4, HRH3, HRH2 | DYRK1A 2218/4885COMT 907/4885PDE10A 2197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.