Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.63 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | MMP3 | P08254 | 5/20 | 0.52 |
| ▸ | MMP2 | P08253 | 3/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11983785 | 0.94 | GSK3B (0.70) | GSK3BCA1CA2RAB9ANPC1 | |
| SCHEMBL9251049 | 0.91 | GSK3B (0.58) | GSK3BCA1CA2MMP3MMP2 | |
| SCHEMBL17973377 | 0.89 | GSK3B (0.56) | GSK3BCA1CA2MMP3MMP2 | |
| SCHEMBL28043310 | 0.86 | KMT2A (0.65) | GSK3BCA1CA2RAB9ANPC1 | |
| SCHEMBL19367865 | 0.85 | GSK3B (0.59) | GSK3BCA1CA2RAB9ANPC1 | |
| SCHEMBL6291931 | 0.85 | GSK3B (0.89) | GSK3BCA1CA2MMP3MMP2 | |
| SCHEMBL7981349 | 0.84 | GSK3B (0.63) | GSK3BCA1CA2MMP2RAB9A | |
| SCHEMBL3362638 | 0.82 | GSK3B (0.61) | GSK3BCA1CA2RAB9ANPC1 | |
| SCHEMBL11060488 | 0.82 | GSK3B (0.61) | GSK3BCA1CA2RAB9ANPC1 | |
| SCHEMBL7862874 | 0.82 | SMN1; SMN2 (0.66) | GSK3BCA1CA2MMP3MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180022996-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2018-01-25 | — | — | US | disclosed |
| US-20170342324-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2017-11-30 | — | — | US | disclosed |
| WO-2016107664-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2016-07-07 | — | — | WO | disclosed |
| WO-2016096082-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MERCK PATENT GMBH (DE) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170342324-A1 | BIMESOGENIC COMPOUNDS AND MESOGENIC MEDIA | MTX1, S100A11, MCRS1 | GSK3B 746/4885CA1 213/4885CA2 806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.