Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.71 |
| ▸ | PAK4 | O96013 | 2/20 | 0.71 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.71 |
| ▸ | GPR183 | P32249 | 3/20 | 0.38 |
| ▸ | LIPC | P11150 | 3/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17859225 | 0.88 | NAMPT (0.76) | NAMPTPAK4PAK1GPR183LIPC | |
| SCHEMBL17859239 | 0.88 | PAK4 (0.59) | NAMPTPAK4PAK1GPR183LIPC | |
| SCHEMBL17844682 | 0.83 | PAK4 (0.47) | NAMPTPAK4PAK1LIPCHDAC1 | |
| Padnarsertib SCHEMBL29649112 | 0.83 | PAK4 (1.00) | NAMPTPAK4PAK1GPR183LIPC | |
| Padnarsertib SCHEMBL16345416 | 0.83 | PAK4 (1.00) | NAMPTPAK4PAK1GPR183LIPC | |
| Padnarsertib SCHEMBL29649080 | 0.83 | PAK4 (1.00) | NAMPTPAK4PAK1GPR183LIPC | |
| Padnarsertib SCHEMBL16348032 | 0.83 | PAK4 (1.00) | NAMPTPAK4PAK1GPR183LIPC | |
| SCHEMBL18530564 | 0.82 | PAK4 (0.66) | NAMPTPAK4PAK1GPR183LIPC | |
| SCHEMBL18530565 | 0.82 | PAK4 (0.66) | NAMPTPAK4PAK1GPR183LIPC | |
| SCHEMBL17859238 | 0.81 | PAK4 (0.59) | NAMPTPAK4PAK1GPR183LIPC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170369470-A1 | Cyclic Compounds and Uses Thereof | Karyopharm Therapeutics Inc. | 2017-12-28 | — | — | US | disclosed |
| WO-2016100515-A1 | CYCLIC COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. (US) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170369470-A1 | Cyclic Compounds and Uses Thereof | MALT1, BCL9, BCL6 | NAMPT 1646/4885PAK4 1077/4885PAK1 1131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.