Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 2/20 | 1.00 |
| ▸ | NAMPT | P43490 | 2/20 | 1.00 |
| ▸ | PAK1 | Q13153 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | BCR | P11274 | 2/20 | 0.33 |
| ▸ | LIPC | P11150 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Padnarsertib SCHEMBL29649080 | 1.00 | PAK4 (1.00) | PAK4NAMPTPAK1HPGDMEN1 | |
| Padnarsertib SCHEMBL16348032 | 1.00 | PAK4 (1.00) | PAK4NAMPTPAK1HPGDMEN1 | |
| Padnarsertib SCHEMBL16345416 | 1.00 | PAK4 (1.00) | PAK4NAMPTPAK1HPGDMEN1 | |
| SCHEMBL18317344 | 0.95 | PAK4 (0.91) | PAK4NAMPTPAK1HPGDMEN1 | |
| SCHEMBL16345152 | 0.95 | PAK4 (0.91) | PAK4NAMPTPAK1HPGDMEN1 | |
| SCHEMBL18317336 | 0.94 | PAK4 (0.89) | PAK4NAMPTPAK1HPGDHDAC3 | |
| SCHEMBL16347424 | 0.94 | NAMPT (0.89) | PAK4NAMPTPAK1GSK3BMTOR | |
| SCHEMBL18317518 | 0.94 | PAK4 (0.89) | PAK4NAMPTPAK1SMN1; SMN2GPR183 | |
| SCHEMBL16345295 | 0.94 | NAMPT (0.89) | PAK4NAMPTPAK1GSK3BMTOR | |
| SCHEMBL31622616 | 0.94 | NAMPT (0.89) | PAK4NAMPTPAK1GSK3BMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260085064-A1 | SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF | KARYOPHARM THERAPEUTICS INC (US) | 2026-03-26 | — | — | US | disclosed |
| US-20260069581-A1 | METHODS AND COMPOSITIONS FOR CANCER THERAPY | OHIO STATE INNOVATION FOUNDATION (US) | 2026-03-12 | — | — | US | disclosed |
| US-12331040-B2 | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | Karyopharm Therapeutics Inc. (US) | 2025-06-17 | — | — | US | disclosed |
| WO-2024120442-A1 | PAK4 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | CONVERGEN (SUZHOU) PHARMACEUTICAL CO., LTD. (CN) | 2024-06-13 | — | — | WO | disclosed |
| WO-2022104108-A1 | METHODS AND COMPOSITIONS FOR CANCER THERAPY | OHIO STATE INNOVATION FOUNDATION (US) | 2022-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12331040-B2 | Substituted benzofuranyl and benzoxazolyl compounds and uses thereof | BCL6, MALT1, BTK | PAK4 2260/4885NAMPT 1782/4885PAK1 3233/4885 |
| US-20260069581-A1 | METHODS AND COMPOSITIONS FOR CANCER THERAPY | HDAC8, HDAC3, SIRT1 | PAK4 1374/4885NAMPT 12/4885PAK1 1070/4885 |
| US-20260085064-A1 | SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF | BCL6, MALT1, BCL6B | PAK4 4159/4885NAMPT 4695/4885PAK1 4775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.