Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 19/20 | 0.88 |
| ▸ | BTK | Q06187 | 3/20 | 0.75 |
| ▸ | LCK | P06239 | 2/20 | 0.75 |
| ▸ | KDR | P35968 | 1/20 | 0.75 |
| ▸ | JAK3 | P52333 | 1/20 | 0.75 |
| ▸ | TEK | Q02763 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30338308 | 0.88 | TNK2 (0.87) | TNK2BTKLCKKDRJAK3 | |
| SCHEMBL2949506 | 0.88 | TNK2 (0.87) | TNK2BTKLCKKDRJAK3 | |
| SCHEMBL30338625 | 0.88 | TNK2 (1.00) | TNK2BTKLCKKDRJAK3 | |
| SCHEMBL30339004 | 0.85 | TNK2 (1.00) | TNK2BTKLCKKDRJAK3 | |
| SCHEMBL2958052 | 0.85 | TNK2 (0.84) | TNK2BTKLCKKDRJAK3 | |
| SCHEMBL30338409 | 0.85 | TNK2 (0.84) | TNK2BTKLCKKDRJAK3 | |
| SCHEMBL4754683 | 0.84 | TNK2 (0.79) | TNK2BTKLCKKDRJAK3 | |
| SCHEMBL30338403 | 0.81 | TNK2 (1.00) | TNK2BTKLCKKDRJAK3 | |
| SCHEMBL30338571 | 0.80 | TNK2 (1.00) | TNK2BTKLCKKDRJAK3 | |
| SCHEMBL30338621 | 0.80 | TNK2 (1.00) | TNK2BTKLCKKDRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9850216-B2 | Inhibitors of ACK1/TNK2 tyrosine kinase | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-12-26 | — | — | US | disclosed |
| US-20160176826-A1 | INHIBITORS OF ACK1/TNK2 TYROSINE KINASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160176826-A1 | INHIBITORS OF ACK1/TNK2 TYROSINE KINASE | TNK1, TNNI3K, TNK2 | TNK2 3/4885BTK 448/4885LCK 148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.