Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 11/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17859426 | 0.93 | PAK4 (0.41) | PAK4GABRA5STAT3HRH3 | |
| SCHEMBL17859425 | 0.92 | PAK4 (0.41) | PAK4GABRA5STAT3HRH3 | |
| SCHEMBL17844731 | 0.90 | PAK4 (0.34) | PAK4STAT3 | |
| SCHEMBL17844692 | 0.90 | PAK4 (0.40) | PAK4GABRA5STAT3HRH3 | |
| SCHEMBL17844713 | 0.88 | PAK4 (0.43) | PAK4GABRA5STAT3HRH3NAMPT | |
| SCHEMBL19753597 | 0.88 | GABRA5 (0.44) | PAK4GABRA5STAT3HRH3 | |
| SCHEMBL17859423 | 0.87 | GABRA5 (0.41) | PAK4GABRA5STAT3HRH3 | |
| SCHEMBL17859496 | 0.85 | PAK4 (0.39) | PAK4GABRA5STAT3NAMPT | |
| SCHEMBL17859532 | 0.85 | PAK4 (0.41) | PAK4GABRA5STAT3 | |
| SCHEMBL29611290 | 0.83 | PAK4 (0.52) | PAK4GABRA5STAT3HRH3NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170369470-A1 | Cyclic Compounds and Uses Thereof | Karyopharm Therapeutics Inc. | 2017-12-28 | — | — | US | disclosed |
| WO-2016100515-A1 | CYCLIC COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. (US) | 2016-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170369470-A1 | Cyclic Compounds and Uses Thereof | MALT1, BCL9, BCL6 | PAK4 1077/4885GABRA5 2240/4885STAT3 91/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.