Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG1 | P19174 | 4/20 | 0.67 |
| ▸ | PLCB3 | Q01970 | 4/20 | 0.67 |
| ▸ | PAX8 | Q06710 | 8/20 | 0.63 |
| ▸ | CASP6 | P55212 | 1/20 | 0.59 |
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860399 | 0.93 | PLCG1 (0.65) | PLCG1PLCB3PAX8CASP6MEN1 | |
| SCHEMBL17860417 | 0.91 | PLCG1 (0.58) | PLCG1PLCB3PAX8CASP6MEN1 | |
| SCHEMBL17860347 | 0.91 | PLCG1 (0.66) | PLCG1PLCB3PAX8CASP6MEN1 | |
| SCHEMBL17860410 | 0.91 | PLCG1 (0.75) | PLCG1PLCB3PAX8CASP6MEN1 | |
| SCHEMBL17860472 | 0.89 | PLCG1 (0.59) | PLCG1PLCB3PAX8CASP6MEN1 | |
| SCHEMBL17860327 | 0.89 | CASP6 (0.73) | PLCG1PLCB3PAX8CASP6MEN1 | |
| SCHEMBL17860379 | 0.88 | PLCG1 (0.60) | PLCG1PLCB3PAX8CASP6MEN1 | |
| SCHEMBL17860476 | 0.88 | PLCG1 (0.57) | PLCG1PLCB3PAX8CASP6MEN1 | |
| SCHEMBL17860436 | 0.87 | PLCG1 (0.66) | PLCG1PLCB3PAX8CASP6MEN1 | |
| SCHEMBL17860353 | 0.87 | PLCG1 (0.66) | PLCG1PLCB3PAX8CASP6RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100711-A1 | MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |