CASP6 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL78538	0.53	19/20
SCHEMBL78539	0.53	19/20
SCHEMBL78540	0.53	19/20
SCHEMBL78288	0.57	15/20
SCHEMBL78289	0.57	15/20
SCHEMBL78290	0.57	15/20
SCHEMBL80166	0.51	14/20
SCHEMBL80167	0.51	14/20
SCHEMBL80168	0.51	14/20
SCHEMBL78880	0.51	9/20
SCHEMBL78881	0.51	9/20
SCHEMBL101829	0.50	4/20
SCHEMBL118229	0.50	4/20
Methysergide (SCHEMBL41844)	1.00	3/20
Methysergide (SCHEMBL41843)	0.90	3/20
SCHEMBL42176	0.55	3/20
SCHEMBL66310	0.52	3/20
SCHEMBL115254	0.51	3/20
SCHEMBL94484	0.49	3/20
SCHEMBL38871	0.47	3/20

Clinical trials — most relevant to CASP6 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Can Vitamin D Reduce Heart Muscle Damage After Bypass Surgery?	PHASE4	COMPLETED
Diet Rich in N-3 Polyunsaturated Fatty Acids in Renal Transplant Recipients	PHASE4	COMPLETED
Clinical Study Evaluating the Anticancer Effect of Pentoxiphylline in Patients With Metastatic Colorectal Cancer	PHASE4	UNKNOWN
Dexmedetomidine to Prevent Hepatic Ischemia-reperfusion Injury-induced Glycocalyx Degradation and Early Allograft Dysfunction in Liver Transplantation	PHASE4	ACTIVE_NOT_RECRUITING
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit	PHASE2/PHASE3	WITHDRAWN
Atorvastatin Calcium, Oligofructose-Enriched Inulin, or Sulindac in Preventing Cancer in Patients at Increased Risk of Developing Colorectal Neoplasia	PHASE2	COMPLETED
Disulfiram in Rheumatoid Arthritis	PHASE2	NOT_YET_RECRUITING
Safety, Tolerability, and Treatment Effect of Belnacasan in Patients With COVID-19	PHASE2	COMPLETED
Esomeprazole Magnesium With or Without Aspirin in Preventing Esophageal Cancer in Patients With Barrett Esophagus	PHASE2	COMPLETED
18F-CP18 Imaging Studies for Cancer Treatment With Birinapant	PHASE2	WITHDRAWN
Supplementation for Male Subfertility	PHASE2	NOT_YET_RECRUITING
Influence of Morphine or Ketamine or Saline Applied During In-hospital Cardiopulmonary Resuscitation on Early Survival	PHASE1	UNKNOWN
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Impact of CASP3 Gene in Chemoresistance	nan	NOT_YET_RECRUITING
Delineating Between Pathophysiologic Phenotypes of Hypoxic Ischemic Brain Injury After Cardiac Arrest	nan	UNKNOWN
Role of Serum ADAM 17 (A Disintegrin And Metalloprotease 17) and Caspase 3 in Patients With Chronic Kidney Disease	nan	NOT_YET_RECRUITING
Potential Role of microRNA 410 and BIRC7 Pathways in Recurrent Spontaneous Miscarriage	nan	COMPLETED
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
Study of CRP, Ferritine and D-Dimer in Covid-19 Patients Admitted To Respiratory ICU in Assuit University Hospitals	nan	UNKNOWN
Analysis of the Variation in Caspase-8 Availability and Cleavage in Oral Squamous Cell Carcinoma	nan	UNKNOWN
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN
Intermittent Fasting for Pancreatitis	nan	NOT_YET_RECRUITING
The Effect of Vitamin E-coated Polysulfone Membrane on Oxidative Stress, Inflammation and Monocytes in Critically Ill Patients in CRRT	nan	UNKNOWN
Effects of Interleukin-6 Inhibition on Vascular, Endothelial and Left Ventricular Function in Rheumatoid Arthritis	nan	UNKNOWN
Apoptosis May Have a Role in Etiopathogenesis of Obstetric Cholestasis.	nan	UNKNOWN
Functional Pharmacogenomics of Childhood Acute Lymphoblastic Leukemia in Taiwan	nan	UNKNOWN
Adipocytokines in Endometrial Cancer	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CASP6 binder may also engage these)

Protein	Name	Similarity
O35397	—	1.000	O35397 →
O08738	—	1.000	O08738 →
Q3T0P5	—	0.997	Q3T0P5 →
A0A1D5PPP7	—	0.993	A0A1D5PPP7 →
Q8MJU1	—	0.981	Q8MJU1 →
Q08DY9	—	0.978	Q08DY9 →
F1NV61	—	0.977	F1NV61 →
Q95ND5	—	0.977	Q95ND5 →
Q8MKI5	—	0.976	Q8MKI5 →
Q5IS54	—	0.973	Q5IS54 →
Q60431	—	0.972	Q60431 →
CASP3	Caspase-3	0.972	landscape →
Q2PFV2	—	0.971	Q2PFV2 →
P55866	—	0.970	P55866 →
P55213	—	0.970	P55213 →
Q5IS99	—	0.969	Q5IS99 →
Q8MJC3	—	0.967	Q8MJC3 →
P70677	—	0.967	P70677 →
CASP8	Caspase-8	0.963	landscape →
O01382	—	0.957	O01382 →
Q9JHX4	—	0.956	Q9JHX4 →
P89116	—	0.955	P89116 →
CASP7	Caspase-7	0.954	landscape →
P97864	—	0.954	P97864 →
CASP2	Caspase-2	0.953	landscape →
P55214	—	0.952	P55214 →
Q98943	—	0.951	Q98943 →
P55215	—	0.950	P55215 →
P29452	—	0.950	P29452 →
O75601	—	0.946	O75601 →