Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG1 | P19174 | 4/20 | 0.56 |
| ▸ | PLCB3 | Q01970 | 4/20 | 0.56 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17860420 | 1.00 | PLCG1 (0.56) | PLCG1PLCB3CASP6PAX8MEN1 | |
| SCHEMBL17860469 | 0.90 | CASP6 (0.61) | PLCG1PLCB3CASP6PAX8MEN1 | |
| SCHEMBL17860421 | 0.89 | PLCG1 (0.59) | PLCG1PLCB3CASP6PAX8MEN1 | |
| SCHEMBL17860298 | 0.88 | PLCG1 (0.62) | PLCG1PLCB3CASP6PAX8MEN1 | |
| SCHEMBL17860379 | 0.87 | PLCG1 (0.60) | PLCG1PLCB3CASP6PAX8MEN1 | |
| SCHEMBL17860445 | 0.87 | PLCG1 (0.60) | PLCG1PLCB3CASP6PAX8MEN1 | |
| SCHEMBL17860427 | 0.87 | PLCG1 (0.56) | PLCG1PLCB3CASP6PAX8MEN1 | |
| SCHEMBL17860441 | 0.86 | PLCG1 (0.62) | PLCG1PLCB3CASP6PAX8MEN1 | |
| SCHEMBL17860353 | 0.86 | PLCG1 (0.66) | PLCG1PLCB3CASP6PAX8MEN1 | |
| SCHEMBL17860440 | 0.86 | PLCG1 (0.62) | PLCG1PLCB3CASP6PAX8MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016100711-A1 | MODULATORS OF HEPATIC LIPOPROTEIN METABOLISM | THE BROAD INSTITUTE, INC. (US) | 2016-06-23 | — | — | WO | disclosed |