⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9558182 | 0.85 | HTR6 (0.36) | — | |
| SCHEMBL8517355 | 0.83 | HTR6 (0.39) | — | |
| SCHEMBL5459528 | 0.80 | DPP4 (0.31) | — | |
| SCHEMBL9558179 | 0.80 | — | — | |
| SCHEMBL3629325 | 0.68 | HTR6 (0.50) | — | |
| SCHEMBL3629329 | 0.68 | HTR6 (0.50) | — | |
| SCHEMBL31208704 | 0.68 | HTR6 (0.50) | — | |
| SCHEMBL3720100 | 0.66 | HTR6 (0.37) | — | |
| SCHEMBL22527652 | 0.65 | HTR6 (0.57) | — | |
| SCHEMBL7473139 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120115845-A1 | THERAPEUTIC AGENTS | ALLEN JACK MCQUEEN (GB) | 2012-05-10 | — | — | US | disclosed |
| US-20110124621-A1 | BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2011-05-26 | — | — | US | disclosed |
| US-20100048543-A1 | PYRIMIDINE COMPOUNDS HAVING TIES (TEK) INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2010-02-25 | — | — | US | disclosed |
| US-20090186870-A1 | Therapeutic Agents - 802 | ASTRAZENECA AB (SE) | 2009-07-23 | — | — | US | disclosed |
| US-20090054632-A1 | Hydrophobically-modified protein compositions and methods | BIOGEN IDEC MA INC. (US) | 2009-02-26 | — | — | US | disclosed |
| US-20080108608-A1 | Pyrimidines With Tie2 (Tek) Activity | ASTRAZENECA AB (SE) | 2008-05-08 | — | — | US | disclosed |
| EP-1577321-A1 | Hydrophobically-modified protein compositions and methods | BIOGEN, INC. (US) | 2005-09-21 | — | — | EP | disclosed |
| US-6897297-B1 | Hydrophobically-modified protein compositions and methods | CURIS, INC. (US) | 2005-05-24 | — | — | US | disclosed |
| EP-1036092-B1 | Hydrophobically-modified hedgehog protein compositions and methods | BIOGEN INC (US) | 2005-05-11 | — | — | EP | disclosed |
| US-20040067980-A1 | Inhibitors of the GPIb-vWF interaction, their preparation and use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2004-04-08 | — | — | US | disclosed |
| US-6444793-B1 | GENETIC ENGINEERING; ACTIVE MATERIALS | CURIS, INC. | 2002-09-03 | — | — | US | disclosed |
| WO-1999028876-A2 | HYDROPHOBICALLY-MODIFIED PROTEIN COMPOSITIONS AND METHODS | BIOGEN, INC. (US) | 1999-06-10 | — | — | WO | disclosed |