SCHEMBL1786340

SCHEMBL1786340

O=C(O)CCC(=O)NCCCNC(=O)c1ccc2oc3ccccc3c(=O)c2c1

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ TTR P02766 2/20 0.55
▸ NPC1 O15118 1/20 0.51
▸ RAB9A P51151 1/20 0.51
▸ ACSL1 P33121 3/20 0.51
▸ ACSL6 Q9UKU0 2/20 0.51
▸ NPSR1 Q6W5P4 1/20 0.46
▸ MAOA P21397 1/20 0.43
▸ BCAT1 P54687 1/20 0.42
▸ MAPK1 P28482 1/20 0.41
▸ LTB4R Q15722 1/20 0.41
▸ KDM4E B2RXH2 1/20 0.41
▸ ALDH1A1 P00352 1/20 0.41
▸ HPGD P15428 1/20 0.41
▸ HSD17B10 Q99714 1/20 0.41
▸ POLB P06746 1/20 0.41
▸ TBK1 Q9UHD2 1/20 0.40
▸ LOXL2 Q9Y4K0 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13653638 0.91 TTR (0.60) TTRNPC1RAB9AACSL1ACSL6
SCHEMBL12608847 0.90 TTR (0.53) TTRNPC1RAB9AACSL1ACSL6
SCHEMBL1787628 0.89 ACSL1 (0.60) TTRNPC1RAB9AACSL1ACSL6
SCHEMBL4236658 0.89 ACSL1 (0.60) TTRNPC1RAB9AACSL1ACSL6
SCHEMBL12608817 0.88 TTR (0.51) TTRNPC1RAB9AACSL1ACSL6
Hydrochloric Acid SCHEMBL1784364 0.87 TTR (0.50) TTRNPC1RAB9AACSL1ACSL6
SCHEMBL4226088 0.83 NPC1 (0.60) TTRNPC1RAB9AACSL1ACSL6
SCHEMBL12608844 0.83 TTR (0.58) TTRNPC1RAB9AACSL1ACSL6
SCHEMBL12608795 0.82 MAPT (0.47) TTRNPC1RAB9AACSL1ACSL6
SCHEMBL12608848 0.82 MAPT (0.47) TTRNPC1RAB9AACSL1ACSL6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8323750-B2 Method of ultraviolet light assisted surface modification and product having a surface formed by this method BEIJING WANHEXINYUAN BIOTECHNOLOGY CO., LTD. (CN) 2012-12-04 — — US disclosed
US-8323750-B2 Method of ultraviolet light assisted surface modification and product having a surface formed by this method BEIJING WANHEXINYUAN BIOTECHNOLOGY CO., LTD. (CN) 2012-12-04 — — US disclosed
US-8323750-B2 Method of ultraviolet light assisted surface modification and product having a surface formed by this method BEIJING WANHEXINYUAN BIOTECHNOLOGY CO., LTD. (CN) 2012-12-04 — — US disclosed
US-20110124766-A1 METHOD OF ULTRAVIOLET LIGHT ASSISTED SURFACE MODIFICATION AN PRODUCT HAVING A SURFACE FORMED BY THIS METHOD BEIJING WANHEXINYUAN BIOTECHNOLOGY CO., LTD. (CN) 2011-05-26 — — US disclosed
US-20110124766-A1 METHOD OF ULTRAVIOLET LIGHT ASSISTED SURFACE MODIFICATION AN PRODUCT HAVING A SURFACE FORMED BY THIS METHOD BEIJING WANHEXINYUAN BIOTECHNOLOGY CO., LTD. (CN) 2011-05-26 — — US disclosed
US-20110124766-A1 METHOD OF ULTRAVIOLET LIGHT ASSISTED SURFACE MODIFICATION AN PRODUCT HAVING A SURFACE FORMED BY THIS METHOD BEIJING WANHEXINYUAN BIOTECHNOLOGY CO., LTD. (CN) 2011-05-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110124766-A1 METHOD OF ULTRAVIOLET LIGHT ASSISTED SURFACE MODIFICATION AN PRODUCT HAVING A SURFACE FORMED BY THIS METHOD XPA, CYBA, PROC TTR 3486/4885NPC1 3805/4885RAB9A 3050/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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