Benzoic Acid

Benzoic Acid

SCHEMBL1786441

CCCC(O)(CC)C(C)O.O=C(O)c1ccccc1.O=C(O)c1ccccc1

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D

The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.44
TSHR P16473 1/20 0.44
NAPRT Q6XQN6 1/20 0.44
CYP2C19 P33261 2/20 0.39
CYP1A2 P05177 2/20 0.39
CYP2D6 P10635 1/20 0.39
CES2 O00748 3/20 0.39
CES1 P23141 3/20 0.39
SRD5A2 P31213 1/20 0.39
PRSS1 P07477 5/20 0.39
CTSG P08311 5/20 0.39
CTRB1 P17538 5/20 0.39
CMA1 P23946 5/20 0.39
PGR P06401 1/20 0.38
ADRA2A P08913 1/20 0.38
ADRA2B P18089 1/20 0.38
HTR2A P28223 1/20 0.38
HRH1 P35367 1/20 0.38
KCNH2 Q12809 1/20 0.38
ALDH1A1 P00352 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzoic Acid SCHEMBL5085460 0.98 DAO (0.42) DAOTSHRNAPRTCYP2C19CYP1A2
Benzoic Acid SCHEMBL4837242 0.94 DAO (0.47) DAOTSHRNAPRTCYP2C19CES2
Benzoic Acid SCHEMBL28021771 0.91 KIF11 (0.43) DAOTSHRNAPRTCES2CES1
Benzoic Acid SCHEMBL1785794 0.90 TSHR (0.50) DAOTSHRNAPRTCYP2C19CYP1A2
Benzoic Acid SCHEMBL27642351 0.88 DAO (0.41) DAOTSHRNAPRTCYP2C19CYP1A2
Benzoic Acid SCHEMBL28025727 0.86 TSHR (0.42) DAOTSHRNAPRTCYP2C19CYP1A2
Benzoic Acid SCHEMBL1784685 0.86 TSHR (0.45) DAOTSHRNAPRTCYP2C19CYP1A2
Benzoic Acid SCHEMBL1785118 0.85 DAO (0.39) DAOTSHRNAPRTCYP2C19CYP1A2
Benzoic Acid SCHEMBL27573803 0.84 TSHR (0.44) DAOTSHRNAPRTCYP2C19CYP2D6
Benzoic Acid SCHEMBL1784165 0.84 DAO (0.38) DAOTSHRNAPRTCYP2C19CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050239636-A1 Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2005-10-27 US claimed
EP-3486263-A2 SELF-LIMITING CATALYST COMPOSITION WITH NO SILANE W.R. Grace & CO. - CONN. (US) 2019-05-22 EP disclosed
EP-2185600-B1 SELF-LIMITING CATALYST COMPOSITION WITH NO SILANE GRACE W R & CO (US) 2018-10-31 EP disclosed
US-9796796-B2 Self-limiting catalyst composition with No silane W. R. GRACE & CO.-CONN. (US) 2017-10-24 US disclosed
EP-1666505-B1 CATALYST COMPONENTS CATALYSTS FOR OLEFINIC POLYMERIZATION AND THE USE THEREOF CHINA PETROLEUM & CHEMICAL (CN) 2016-03-23 EP disclosed
CN-103087222-A Olefin polymerization catalyst, process for producing olefin polymer, polypropylene resin composition and article comprising the same SUMITOMO CHEMICAL CO 2013-05-08 CN disclosed
US-20130109789-A1 OLEFIN POLYMERIZATION CATALYST, PROCESS FOR PRODUCING OLEFIN POLYMER, POLYPROPYLENE RESIN COMPOSITION AND ARTICLE COMPRISING THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-05-02 US disclosed
US-20110124491-A1 Self-Limiting Catalyst Composition with No Silane W. R. GRACE & CO.-CONN. 2011-05-26 US disclosed
EP-2185600-A1 SELF-LIMITING CATALYST COMPOSITION WITH NO SILANE Dow Global Technologies Inc. (US) 2010-05-19 EP disclosed
CN-101565475-A Catalyst component and catalyst thereof for olefinic polymerization CHINA PETROLEUM & CHEMICAL (CN) 2009-10-28 CN disclosed
WO-2009029447-A1 SELF-LIMITING CATALYST COMPOSITION WITH NO SILANE DOW GLOBAL TECHNOLOGIES INC. (US) 2009-03-05 WO disclosed
US-7388061-B2 Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2008-06-17 US disclosed
CN-1310963-C Catalyst component for olefin polymerization reaction and catalyst CHINA PETROCHEMICAL CORP (CN) 2007-04-18 CN disclosed
EP-1666505-A1 CATALYST COMPONENTS CATALYSTS FOR OLEFINIC POLYMERIZATION AND THE USE THEREOF China Petroleum & Chemical Corporation (CN) 2006-06-07 EP disclosed
US-20050239636-A1 Solid catalyst component for polymerization of olefins, catalyst comprising the same and use thereof CHINA PETROLEUM & CHEMICAL CORPORATION (CN) 2005-10-27 US disclosed
CN-1552741-A Catalyst component for olefin polymerization reaction and catalyst 中国石油化工股份有限公司 2004-12-08 CN disclosed
CN-1446197-A Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids WARNER LAMBERT CO (US) 2003-10-01 CN disclosed