Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 15/20 | 0.66 |
| ▸ | RPS6KB1 | P23443 | 15/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 11/20 | 0.66 |
| ▸ | INCENP | Q9NQS7 | 10/20 | 0.66 |
| ▸ | AURKA | O14965 | 4/20 | 0.53 |
| ▸ | AKT2 | P31751 | 1/20 | 0.50 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17865819 | 0.90 | RPS6KB1 (0.78) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL8510809 | 0.90 | RPS6KB1 (0.82) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL18537630 | 0.90 | RPS6KB1 (0.82) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL17865853 | 0.88 | AKT1 (0.69) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL17865845 | 0.88 | AKT1 (0.67) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL17865818 | 0.87 | RPS6KB1 (0.66) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL17865828 | 0.87 | RPS6KB1 (0.61) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL17865814 | 0.87 | AKT1 (0.65) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL17865864 | 0.86 | AKT1 (0.78) | AKT1RPS6KB1AURKBINCENPAURKA | |
| SCHEMBL17865847 | 0.86 | AKT1 (0.79) | AKT1RPS6KB1AURKBINCENPAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643313-B9 | QUINAZOLINE CARBOXAMIDE AZETIDINES | MERCK PATENT GMBH (DE) | 2017-02-22 | — | — | EP | claimed |
| EP-2643313-B1 | QUINAZOLINE CARBOXAMIDE AZETIDINES | MERCK PATENT GMBH (DE) | 2016-06-29 | — | — | EP | claimed |