Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 8/20 | 0.51 |
| ▸ | UBA3 | Q8TBC4 | 7/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | UBA6 | A0AVT1 | 2/20 | 0.51 |
| ▸ | GRK5 | P34947 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.51 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.51 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.41 |
| ▸ | ADK | P55263 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17866001 | 0.95 | NAE1 (0.49) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL17865972 | 0.87 | NAE1 (0.51) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL230987 | 0.87 | NAE1 (0.46) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL230988 | 0.87 | NAE1 (0.46) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL17865955 | 0.87 | NAE1 (0.51) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL17865962 | 0.85 | NAE1 (0.49) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL192354 | 0.85 | NAE1 (0.67) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL17865957 | 0.85 | NAE1 (0.46) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL10004854 | 0.84 | NAE1 (0.52) | NAE1UBA3CA2UBA6GRK5 | |
| SCHEMBL17865920 | 0.83 | METTL3 (0.55) | NAE1UBA3CA2UBA6GRK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | claimed |