Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 6/20 | 0.52 |
| ▸ | UBA6 | A0AVT1 | 5/20 | 0.52 |
| ▸ | UBA3 | Q8TBC4 | 4/20 | 0.52 |
| ▸ | SAE1 | Q9UBE0 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | GRK5 | P34947 | 1/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.52 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.52 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.38 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | ATG7 | O95352 | 1/20 | 0.32 |
| ▸ | UBA7 | P41226 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17865961 | 1.00 | NAE1 (0.52) | NAE1UBA6UBA3SAE1CA2 | |
| SCHEMBL17865931 | 0.91 | NAE1 (0.52) | NAE1UBA6UBA3SAE1CA2 | |
| SCHEMBL17865940 | 0.91 | NAE1 (0.52) | NAE1UBA6UBA3SAE1CA2 | |
| SCHEMBL10005120 | 0.87 | NAE1 (0.67) | NAE1UBA6UBA3SAE1CA2 | |
| SCHEMBL11889842 | 0.87 | NAE1 (0.67) | NAE1UBA6UBA3SAE1CA2 | |
| SCHEMBL746538 | 0.87 | NAE1 (0.67) | NAE1UBA6UBA3SAE1CA2 | |
| SCHEMBL17865983 | 0.85 | NAE1 (0.60) | NAE1UBA6UBA3SAE1CA2 | |
| SCHEMBL17865960 | 0.85 | NAE1 (0.60) | NAE1UBA6UBA3SAE1CA2 | |
| SCHEMBL10004715 | 0.84 | NAE1 (0.61) | NAE1UBA6UBA3SAE1CA2 | |
| SCHEMBL17866060 | 0.84 | NAE1 (0.51) | NAE1UBA6UBA3SAE1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | claimed |