Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 7/20 | 0.67 |
| ▸ | UBA3 | Q8TBC4 | 5/20 | 0.67 |
| ▸ | UBA6 | A0AVT1 | 3/20 | 0.67 |
| ▸ | SAE1 | Q9UBE0 | 3/20 | 0.67 |
| ▸ | CA2 | P00918 | 2/20 | 0.67 |
| ▸ | GRK5 | P34947 | 1/20 | 0.67 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.67 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.67 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.67 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.43 |
| ▸ | ATG7 | O95352 | 1/20 | 0.42 |
| ▸ | UBA7 | P41226 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11889842 | 1.00 | NAE1 (0.67) | NAE1UBA3UBA6SAE1CA2 | |
| SCHEMBL10005120 | 1.00 | NAE1 (0.67) | NAE1UBA3UBA6SAE1CA2 | |
| SCHEMBL10004715 | 0.95 | NAE1 (0.61) | NAE1UBA3UBA6SAE1CA2 | |
| SCHEMBL10004886 | 0.89 | NAE1 (0.61) | NAE1UBA3UBA6SAE1CA2 | |
| SCHEMBL10004720 | 0.89 | NAE1 (0.54) | NAE1UBA3UBA6SAE1CA2 | |
| SCHEMBL10004878 | 0.89 | NAE1 (0.54) | NAE1UBA3UBA6SAE1CA2 | |
| SCHEMBL17865985 | 0.87 | NAE1 (0.52) | NAE1UBA3UBA6SAE1CA2 | |
| SCHEMBL17865931 | 0.87 | NAE1 (0.52) | NAE1UBA3UBA6SAE1CA2 | |
| SCHEMBL17865961 | 0.87 | NAE1 (0.52) | NAE1UBA3UBA6SAE1CA2 | |
| SCHEMBL17865940 | 0.87 | NAE1 (0.52) | NAE1UBA3UBA6SAE1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-B1 | Inhibitors of E1 Activating Enzymes | MILLENNIUM PHARM INC (US) | 2016-06-29 | — | — | EP | claimed |
| EP-1989206-B1 | INHIBITORS OF E1 ACTIVATING ENZYME | MILLENNIUM PHARM INC (US) | 2012-07-04 | — | — | EP | claimed |
| EP-3684363-A4 | COCRYSTAL FORMS OF ((1S,2S,4R)-4-{4-[(1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO]-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL}-2-HYDROXYCYCLOPENTYL) METHYL SULFAMATE, FORMULATIONS AND USES THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2021-05-12 | — | — | EP | disclosed |
| EP-3091020-B1 | HYDROCHLORIDE SALT OF ((1S,2S,4R)-4-{4-[(1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO]-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL}-2-HYDROXYCYCLOPENTYL)METHYL SULFAMATE | MILLENNIUM PHARM INC (US) | 2020-12-30 | — | — | EP | disclosed |
| EP-3684363-A1 | COCRYSTAL FORMS OF ((1S,2S,4R)-4-{4-[(1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO]-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL}-2-HYDROXYCYCLOPENTYL) METHYL SULFAMATE, FORMULATIONS AND USES THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2020-07-29 | — | — | EP | disclosed |
| EP-3091020-A3 | HYDROCHLORIDE SALT OF ((1S,2S,4R)-4-{4-[(1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO]-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL}-2-HYDROXYCYCLOPENTYL)METHYL SULFAMATE | Millennium Pharmaceuticals, Inc. (US) | 2017-01-11 | — | — | EP | disclosed |
| EP-3091020-A2 | HYDROCHLORIDE SALT OF ((1S,2S,4R)-4-{4-[(1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO]-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL}-2-HYDROXYCYCLOPENTYL)METHYL SULFAMATE | Millennium Pharmaceuticals, Inc. (US) | 2016-11-09 | — | — | EP | disclosed |
| EP-2430026-A1 | HYDROCHLORIDE SALT OF ((1S,2S,4R)-4-{4-[(1S)-2,3-DIHYDRO-1H-INDEN-1-YLAMINO]-7H-PYRROLO [2,3-D]PYRIMIDIN-7-YL}-2-HYDROXYCYCLOPENTYL)METHYL SULFAMATE | Millennium Pharmaceuticals, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |