Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.51 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.42 |
| ▸ | SLC1A2 | P43004 | 3/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 3/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.33 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.33 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL8817376 | 1.00 | SLC7A5 (0.51) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL17113855 | 0.97 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL5060410 | 0.97 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL29092653 | 0.97 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| D-Leucine SCHEMBL1537225 | 0.97 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL139230 | 0.97 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL139231 | 0.97 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL17113857 | 0.97 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL756554 | 0.97 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 | |
| Leucine SCHEMBL756553 | 0.97 | SLC7A5 (0.55) | SLC7A5SLC1A3SLC1A2SLC1A1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3983017-A1 | METHODS TO TREAT VIRAL INFECTIONS | The Board Of Trustees Of The Leland Stanford Junior University (US) | 2022-04-20 | — | — | EP | claimed |
| CN-114286692-A | Methods of treating viral infections | 小利兰·斯坦福大学托管委员会 | 2022-04-05 | — | — | CN | claimed |
| WO-2020251941-A1 | METHODS TO TREAT VIRAL INFECTIONS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2020-12-17 | — | — | WO | claimed |
| US-20190033313-A1 | METHODS AND SYSTEMS FOR DETECTING MELANOMA | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2019-01-31 | — | — | US | claimed |
| WO-2016196743-A1 | METHODS AND SYSTEMS FOR DETECTING MELANOMA | THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-12-08 | — | — | WO | claimed |
| WO-2023225654-A1 | METHODS AND COMPOSITIONS FOR TREATING OBESITY, OBESITY-RELATED DISEASES, FATTY LIVER AND FATTY LIVER ASSOCIATED DISEASES WITH ANTI-CD24 AGENTS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2023-11-23 | — | — | WO | disclosed |
| EP-3983017-A1 | METHODS TO TREAT VIRAL INFECTIONS | The Board Of Trustees Of The Leland Stanford Junior University (US) | 2022-04-20 | — | — | EP | disclosed |
| CN-114286692-A | Methods of treating viral infections | 小利兰·斯坦福大学托管委员会 | 2022-04-05 | — | — | CN | disclosed |
| WO-2020251941-A1 | METHODS TO TREAT VIRAL INFECTIONS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2020-12-17 | — | — | WO | disclosed |
| US-20190033313-A1 | METHODS AND SYSTEMS FOR DETECTING MELANOMA | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2019-01-31 | — | — | US | disclosed |
| WO-2016196743-A1 | METHODS AND SYSTEMS FOR DETECTING MELANOMA | THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2016-12-08 | — | — | WO | disclosed |
| US-8614301-B2 | Methods of treating cancer using anti CD24 antibodies | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center (IL) | 2013-12-24 | — | — | US | disclosed |
| EP-2222697-A2 | IMMUNOSUPPRESSIVE POLYPEPTIDES AND NUCLEIC ACIDS | Perseid Therapeutics LLC (US) | 2010-09-01 | — | — | EP | disclosed |
| EP-2209492-A1 | METHODS OF TREATING CANCER USING ANTI CD24 ANTIBODIES | The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center (IL) | 2010-07-28 | — | — | EP | disclosed |
| US-20090258031-A1 | IMMUNOSUPPRESSIVE POLYPEPTIDES AND NUCLEIC ACIDS | MAXYGEN, INC. (US) | 2009-10-15 | — | — | US | disclosed |
| WO-2009063461-A1 | METHODS OF TREATING CANCER USING ANTI CD24 ANTIBODIES | THE MEDICAL RESEARCH, INFRASTRUCTURE, AND HEALTH SERVICES FUND OF THE TEL AVIV MEDICAL CENTER (IL) | 2009-05-22 | — | — | WO | disclosed |
| WO-2009058564-A2 | IMMUNOSUPPRESSIVE POLYPEPTIDES AND NUCLEIC ACIDS | MAXYGEN, INC. (US) | 2009-05-07 | — | — | WO | disclosed |
| US-5952471-A | ANTIBODY THAT BINDS TO EPITOPE CONTAINING VALINE AMINO ACID; DIAGNOSIS; ANTICARCINOGENIC AGENTS | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-09-14 | — | — | US | disclosed |
| WO-1997014795-A1 | TUMOR ASSOCIATED POLYPEPTIDES WITH CARBOXYL-TERMINAL ALANINE-PROLINE, PROLINE-PROLINE OR GLYCINE-PROLINE AND ANTIBODIES THERETO | JOHN WAYNE CANCER INSTITUTE (US) | 1997-04-24 | — | — | WO | disclosed |
| WO-1996004312-A1 | SMALL CELL LUNG CARCINOMA PEPTIDES AND BINDING AGENTS | CELLTECH THERAPEUTICS LIMITED (GB) | 1996-02-15 | — | — | WO | disclosed |