SCHEMBL17867251

SCHEMBL17867251

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nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.41
CYP2C9 P11712 1/20 0.38
PDE4A P27815 1/20 0.38
PAX8 Q06710 1/20 0.34
USP2 O75604 1/20 0.31
SLCO1B1 Q9Y6L6 1/20 0.31
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17867373 1.00 TSHR (0.41) TSHRCYP2C9PDE4APAX8USP2
SCHEMBL7152565 1.00 TSHR (0.41) TSHRCYP2C9PDE4APAX8USP2
SCHEMBL2263460 0.86 PDE4A (0.43) TSHRCYP2C9PDE4APAX8USP2
SCHEMBL7149416 0.86 PDE4A (0.43) TSHRCYP2C9PDE4APAX8USP2
SCHEMBL7150290 0.86 PDE4A (0.43) TSHRCYP2C9PDE4APAX8USP2
SCHEMBL3190386 0.86 PDE4A (0.43) TSHRCYP2C9PDE4APAX8USP2
SCHEMBL3433527 0.86 PDE4A (0.43) TSHRCYP2C9PDE4APAX8USP2
SCHEMBL150614 0.86 PDE4A (0.43) TSHRCYP2C9PDE4APAX8USP2
SCHEMBL208916 0.86 PDE4A (0.43) TSHRCYP2C9PDE4APAX8USP2
SCHEMBL7155653 0.86 PDE4A (0.43) TSHRCYP2C9PDE4APAX8USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11421223-B2 Processes and host cells for genome, pathway, and biomolecular engineering ENEVOLV, INC. (US) 2022-08-23 US disclosed
US-20190309289-A1 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING ENEVOLV, INC. 2019-10-10 US disclosed
US-10370654-B2 Processes and host cells for genome, pathway, and biomolecular engineering ENEVOLV, INC. (US) 2019-08-06 US disclosed
US-20180320170-A1 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING ENEVOLV, INC. 2018-11-08 US disclosed
US-9944925-B2 Processes and host cells for genome, pathway, and biomolecular engineering ENEVOLV, INC. 2018-04-17 US disclosed
US-20160186168-A1 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING ENEVOLV, INC. 2016-06-30 US disclosed