SCHEMBL17867642

SCHEMBL17867642

COC(=O)c1ncncc1-c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 2/20 0.50
SRC P12931 2/20 0.50
FGFR2 P21802 2/20 0.50
FGFR4 P22455 2/20 0.50
FGFR3 P22607 2/20 0.50
GABRA1 P14867 1/20 0.48
GABRG2 P18507 1/20 0.48
GABRB3 P28472 1/20 0.48
GABRA5 P31644 1/20 0.48
GABRA3 P34903 1/20 0.48
SMN1; SMN2 Q16637 3/20 0.48
NCOA1 Q15788 1/20 0.47
NCOA3 Q9Y6Q9 1/20 0.47
ALDH1A1 P00352 5/20 0.44
HSD17B10 Q99714 5/20 0.44
HPGD P15428 3/20 0.44
KDM4E B2RXH2 3/20 0.44
HTT P42858 1/20 0.43
CYP1A2 P05177 2/20 0.43
CYP3A4 P08684 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19479973 0.82 NCOA1 (0.43) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL25310178 0.81 CYP3A4 (0.59) ALDH1A1HSD17B10HPGDKDM4ECYP1A2
SCHEMBL698991 0.78 L3MBTL1 (0.55) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL26599244 0.77 CYP3A4 (0.37) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL13531230 0.75 MAPT (0.50) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL13734214 0.74 L3MBTL1 (0.51) ALDH1A1HTTALOX15L3MBTL1NEK1
SCHEMBL13943352 0.73 NPSR1 (0.45) ALDH1A1HSD17B10KDM4EHTTL3MBTL1
SCHEMBL30143994 0.73 NPSR1 (0.45) ALDH1A1KDM4ECYP3A4L3MBTL1MAPK1
SCHEMBL30640097 0.73 LRRK2 (0.43) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL29108557 0.73 LRRK2 (0.43) FGFR1SRCFGFR2FGFR4FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116874433-A Pyrimidine compound and synthetic method and application thereof 上海应用技术大学 2023-10-13 CN disclosed
EP-3040395-B1 ORGANIC MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME LUMINESCENCE TECH CORP (TW) 2017-10-18 EP disclosed
US-9793493-B2 Organic material and organic electroluminescent device using the same LUMINESCENCE TECHNOLOGY CORP. (TW) 2017-10-17 US disclosed
US-9793493-B2 Organic material and organic electroluminescent device using the same LUMINESCENCE TECHNOLOGY CORP. (TW) 2017-10-17 US disclosed
US-9793493-B2 Organic material and organic electroluminescent device using the same LUMINESCENCE TECHNOLOGY CORP. (TW) 2017-10-17 US disclosed
EP-3040395-A1 ORGANIC MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME Luminescence Technology Corp. (TW) 2016-07-06 EP disclosed
US-20160190472-A1 ORGANIC MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME LUMINESCENCE TECHNOLOGY CORP. 2016-06-30 US disclosed
US-20160190472-A1 ORGANIC MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME LUMINESCENCE TECHNOLOGY CORP. 2016-06-30 US disclosed
US-20160190472-A1 ORGANIC MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME LUMINESCENCE TECHNOLOGY CORP. 2016-06-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160190472-A1 ORGANIC MATERIAL AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME EBPL, OXA1L, HBS1L FGFR1 4500/4885SRC 2771/4885FGFR2 4509/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.