Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17868821 | 0.84 | CDK1 (0.46) | PARP1SLC6A2SLC6A4SLC6A3HTR2C | |
| SCHEMBL17868818 | 0.83 | PARP1 (0.46) | PARP1SLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL15380385 | 0.82 | SLC6A2 (0.49) | PARP1SLC6A2SLC6A4SLC6A3HTR2C | |
| SCHEMBL3809365 | 0.80 | PARP1 (0.51) | PARP1HTR2CPARP2RPS6KB1 | |
| SCHEMBL22611748 | 0.80 | PARP1 (0.50) | PARP1SLC6A2SLC6A4SLC6A3PARP2 | |
| SCHEMBL22611547 | 0.80 | PARP1 (0.50) | PARP1SLC6A2SLC6A4SLC6A3PARP2 | |
| SCHEMBL22611822 | 0.80 | PARP1 (0.50) | PARP1SLC6A2SLC6A4SLC6A3PARP2 | |
| SCHEMBL15378067 | 0.79 | PARP1 (0.43) | PARP1HTR2C | |
| SCHEMBL17868824 | 0.79 | PARP1 (0.42) | PARP1 | |
| SCHEMBL28325510 | 0.78 | PARP1 (0.57) | PARP1PARP2RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170135994-A9 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-20160184282-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2016-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160184282-A1 | NAMPT INHIBITORS | NAMPT, NNMT, NAPRT | PARP1 1174/4885SLC6A2 920/4885SLC6A4 1993/4885 |
| US-20170135994-A9 | NAMPT INHIBITORS | NAMPT, NNMT, NAPRT | PARP1 1174/4885SLC6A2 920/4885SLC6A4 1993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.