Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | FNTA | P49354 | 2/20 | 0.45 |
| ▸ | FNTB | P49356 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.44 |
| ▸ | SQLE | Q14534 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL157735 | 0.95 | — | — | |
| SCHEMBL28009409 | 0.95 | KDM4E (0.62) | POLBKDM4EATMKMT2AALDH1A1 | |
| Bicarbonate SCHEMBL28331616 | 0.90 | KDM4E (0.64) | POLBKDM4EATMKMT2AALDH1A1 | |
| Formaldehyde SCHEMBL4563394 | 0.90 | KDM4E (0.58) | POLBKDM4EATMKMT2AALDH1A1 | |
| Formic Acid SCHEMBL28331617 | 0.87 | KDM4E (0.56) | POLBKDM4EATMKMT2AALDH1A1 | |
| SCHEMBL3111482 | 0.85 | KMT2A (0.73) | POLBKDM4EATMKMT2AALDH1A1 | |
| SCHEMBL14236831 | 0.85 | KMT2A (0.73) | POLBKDM4EATMKMT2AALDH1A1 | |
| SCHEMBL112856 | 0.85 | KMT2A (0.73) | POLBKDM4EATMKMT2AALDH1A1 | |
| SCHEMBL157509 | 0.85 | KMT2A (0.73) | POLBKDM4EATMKMT2AALDH1A1 | |
| SCHEMBL790270 | 0.85 | KMT2A (0.73) | POLBKDM4EATMKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016105448-A1 | IMIDAZOLINE RECEPTOR TYPE 1 LIGANDS FOR USE AS THERAPEUTICS | RIDEOUT DARRYL (US) | 2016-06-30 | — | — | WO | disclosed |
| WO-2016105449-A1 | COMPOUNDS FOR USE AS PAIN THERAPEUTICS | LEDERMAN SETH (US) | 2016-06-30 | — | — | WO | disclosed |