Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 4/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17871067 | 0.92 | L3MBTL1 (0.34) | L3MBTL1AAK1CYP3A4PIK3C3MAPKAPK2 | |
| SCHEMBL17840827 | 0.90 | L3MBTL1 (0.36) | L3MBTL1AAK1CYP3A4PIK3C3MAPKAPK2 | |
| SCHEMBL17840898 | 0.84 | L3MBTL1 (0.38) | L3MBTL1AAK1CYP3A4PIK3C3MAPKAPK2 | |
| SCHEMBL17840582 | 0.83 | TYK2 (0.41) | L3MBTL1PIK3C3MAPKAPK2MAPK14ACVRL1 | |
| SCHEMBL30365666 | 0.83 | TYK2 (0.41) | L3MBTL1PIK3C3MAPKAPK2MAPK14ACVRL1 | |
| SCHEMBL17840563 | 0.82 | CYP1A2 (0.40) | L3MBTL1AAK1CYP3A4PIK3C3ACACB | |
| SCHEMBL17871068 | 0.82 | PIK3C3 (0.38) | L3MBTL1AAK1CYP3A4PIK3C3JAK2 | |
| SCHEMBL17840751 | 0.82 | AAK1 (0.40) | L3MBTL1AAK1CYP3A4PIK3C3MAPKAPK2 | |
| SCHEMBL17840721 | 0.81 | AAK1 (0.37) | L3MBTL1AAK1CYP3A4MAPKAPK2MAPK14 | |
| SCHEMBL17840655 | 0.81 | AAK1 (0.38) | L3MBTL1AAK1CYP3A4PIK3C3MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237415-A1 | TGF RECEPTOR ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2017-11-01 | — | — | EP | disclosed |
| WO-2016106266-A1 | TGFβ RECEPTOR ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-06-30 | — | — | WO | disclosed |