Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 19/20 | 0.55 |
| ▸ | MMP2 | P08253 | 5/20 | 0.54 |
| ▸ | MMP14 | P50281 | 3/20 | 0.54 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21582804 | 0.81 | ADAMTS5 (0.73) | ADAMTS5MMP2MMP14ADAMTS4 | |
| SCHEMBL17871443 | 0.80 | ADAMTS5 (0.58) | ADAMTS5MMP2MMP14ADAMTS4 | |
| SCHEMBL29867830 | 0.72 | ADAMTS5 (0.55) | ADAMTS5MMP2MMP14ADAMTS4 | |
| SCHEMBL20708257 | 0.71 | ADAMTS5 (0.69) | ADAMTS5MMP2MMP14ADAMTS4 | |
| SCHEMBL17871537 | 0.71 | ADAMTS5 (1.00) | ADAMTS5MMP2MMP14ADAMTS4 | |
| Aldumastat SCHEMBL17871211 | 0.70 | ADAMTS5 (1.00) | ADAMTS5MMP2MMP14ADAMTS4 | |
| Aldumastat SCHEMBL17871325 | 0.70 | ADAMTS5 (1.00) | ADAMTS5MMP2MMP14ADAMTS4 | |
| Aldumastat SCHEMBL17884630 | 0.70 | ADAMTS5 (1.00) | ADAMTS5MMP2MMP14ADAMTS4 | |
| SCHEMBL30609664 | 0.70 | ADAMTS5 (0.64) | ADAMTS5MMP2MMP14ADAMTS4 | |
| SCHEMBL17884967 | 0.70 | ADAMTS5 (0.64) | ADAMTS5MMP2MMP14ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4263530-A1 | SOLID FORMS OF (5S)-CYCLOPROPYL-5-[3-[(3S)-4-(3,5-DIFLUOROPHENYL)-3-METHYL-PIPERAZIN-1-YL]-3-OXO-PROPYL]IMIDAZOLIDINE-2,4-DIONE | Galapagos N.V. (BE) | 2023-10-25 | — | — | EP | claimed |
| WO-2022128849-A1 | SOLID FORMS OF (5S)-CYCLOPROPYL-5-[3-[(3S)-4-(3,5-DIFLUOROPHENYL)-3-METHYL-PIPERAZIN-1-YL]-3-OXO-PROPYL]IMIDAZOLIDINE-2,4-DIONE | GALAPAGOS NV (BE) | 2022-06-23 | — | — | WO | claimed |
| EP-3237406-A1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | Galapagos NV (BE) | 2017-11-01 | — | — | EP | claimed |
| WO-2016102347-A1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2016-06-30 | — | — | WO | claimed |
| EP-4263530-A1 | SOLID FORMS OF (5S)-CYCLOPROPYL-5-[3-[(3S)-4-(3,5-DIFLUOROPHENYL)-3-METHYL-PIPERAZIN-1-YL]-3-OXO-PROPYL]IMIDAZOLIDINE-2,4-DIONE | Galapagos N.V. (BE) | 2023-10-25 | — | — | EP | disclosed |
| WO-2022128849-A1 | SOLID FORMS OF (5S)-CYCLOPROPYL-5-[3-[(3S)-4-(3,5-DIFLUOROPHENYL)-3-METHYL-PIPERAZIN-1-YL]-3-OXO-PROPYL]IMIDAZOLIDINE-2,4-DIONE | GALAPAGOS NV (BE) | 2022-06-23 | — | — | WO | disclosed |
| EP-3237406-A1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | Galapagos NV (BE) | 2017-11-01 | — | — | EP | disclosed |
| WO-2016102347-A1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2016-06-30 | — | — | WO | disclosed |