ADAMTS5 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL610254	0.76	16/20
SCHEMBL607476	0.67	15/20
SCHEMBL609432	0.65	15/20
SCHEMBL611157	0.78	14/20
SCHEMBL610639	0.68	14/20
SCHEMBL610739	0.67	14/20
SCHEMBL610546	0.65	14/20
SCHEMBL608917	0.78	13/20
SCHEMBL610665	0.74	13/20
SCHEMBL607923	0.62	13/20
SCHEMBL762368	0.50	13/20
SCHEMBL762369	0.50	13/20
SCHEMBL855440	0.36	11/20
SCHEMBL610570	0.61	10/20
SCHEMBL609006	0.84	9/20
SCHEMBL609111	0.63	9/20
SCHEMBL207068	0.46	9/20
SCHEMBL855469	0.33	9/20
SCHEMBL14762	0.55	8/20
SCHEMBL205991	0.47	8/20

Clinical trials — most relevant to ADAMTS5 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Prophylactic Plasma Infusion Therapy for Congenital Thrombotic Thrombocytopenic Purpura	PHASE4	WITHDRAWN
Efficacy of Pioglitazone and Metformin on Cardiovascular Risk in Subjects With Insulin-Treated Type 2 Diabetes Mellitus.	PHASE4	COMPLETED
PRP in ACLR to Prevent PTOA	PHASE3	RECRUITING
Aspirin for Prophylaxis of TTP	PHASE2/PHASE3	NOT_YET_RECRUITING
A Study of AA4500 in Men With Peyronie's Disease	PHASE3	COMPLETED
Sputum Matrix Metalloproteinases (MMP) mRNA and Montelukast	PHASE2	COMPLETED
Synvisc to Treat Osteoarthritis of the Temporomandibular Joint	PHASE2	COMPLETED
The Use of Rituximab in Acute Thrombotic Thrombocytopenic Purpura (TTP)	PHASE2	COMPLETED
Phase 1 Dose Escalation, Single Dose Study to Assess Safety and Pharmacokinetics of BAX930 in Hereditary Thrombotic Thrombocytopenic Purpura (TTP)	PHASE1	COMPLETED
The Role of Matrix Metalloproteinases (MMPs) in Orthodontic Tooth Movement	PHASE1	COMPLETED
ADAMTS-13 LEVEL AS PREDICTIVE BIOMARKER FOR DEVELOPMENT OF PORTAL VEIN THROMBOSIS IN LIVER CIRRHOSIS (ADAPTHRO)	nan	UNKNOWN
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction	nan	COMPLETED
Extracellular Matrix Remodeling of the Umbilical Cord and Placenta in Preeclampsia	nan	UNKNOWN
Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects	nan	AVAILABLE
ADAMTS13 in Thrombotic Thrombocytopenic Purpura	nan	COMPLETED
Prognostic Indices of Atheromatosis Severity and Coronary Artery Bypass Surgery Outcomes for Patients With Coronary Artery Disease	nan	ACTIVE_NOT_RECRUITING
Apoptotic Changes in Gingiva Caused by Smoking	nan	COMPLETED
A Retrospective, Observational Study on the Response to Caplacizumab Treatment in aTTP Patients: the Italian Experience (ROSCAPLI)	nan	UNKNOWN
Screening of TMA Patients für ADAMTS13 Activity (Adamscreen)	nan	UNKNOWN
Elevated Plasma Levels of TIMP-1 in Patients With Rotator Cuff Tear	nan	COMPLETED
Matrix Metalloproteinases After Surgery and/or Radiofrequency Ablation in Patients With Liver Metastases From Colorectal Cancer	nan	COMPLETED
Matrix Metalloproteinases 7 and 9 in Rheumatoid Arthritis Patients With Interstitial Lung Disease	nan	NOT_YET_RECRUITING
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence	nan	WITHDRAWN
Peri-implantitis and MMP-8	nan	COMPLETED
Association Between Matrix Metalloproteinase-2 Gene Polymorphism rs243865 and Susceptibility to Cataract Development	nan	COMPLETED
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma	nan	UNKNOWN
LRP1 and Colon Cancer	nan	UNKNOWN
Biomarkers in Post Thrombotic Syndrome	nan	COMPLETED
Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial	nan	COMPLETED
Plasma Levels of Matrix Metalloproteinases (MMPs) and Degree of DNA Fragmentation in Pseudoexfoliation (PEX) Glaucoma	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ADAMTS5 binder may also engage these)

Protein	Name	Similarity
Q9R001	—	0.996	Q9R001 →
P97857	—	0.995	P97857 →
P59384	—	0.994	P59384 →
Q8TE58	—	0.994	Q8TE58 →
ADAMTS1	A disintegrin and metalloproteinase with thrombospondin motifs 1	0.994	landscape →
Q8WXS8	—	0.992	Q8WXS8 →
P59511	—	0.990	P59511 →
Q4VC17	—	0.990	Q4VC17 →
Q69Z28	—	0.989	Q69Z28 →
Q8TE57	—	0.988	Q8TE57 →
O95450	—	0.987	O95450 →
Q9WUQ1	—	0.987	Q9WUQ1 →
Q9H324	—	0.987	Q9H324 →
Q8TE60	—	0.986	Q8TE60 →
P58459	—	0.986	P58459 →
Q9TT93	—	0.985	Q9TT93 →
Q8C9W3	—	0.985	Q8C9W3 →
P79331	—	0.984	P79331 →
Q9P2N4	—	0.983	Q9P2N4 →
Q9ESP7	—	0.983	Q9ESP7 →
P57110	—	0.983	P57110 →
ADAMTS7	A disintegrin and metalloproteinase with thrombospondin motifs 7	0.983	landscape →
P59510	—	0.983	P59510 →
Q19791	—	0.982	Q19791 →
Q68SA9	—	0.982	Q68SA9 →
Q1EHB3	—	0.982	Q1EHB3 →
Q8BNJ2	—	0.982	Q8BNJ2 →
P19336	—	0.981	P19336 →
O15072	—	0.981	O15072 →
ADAMTS12	A disintegrin and metalloproteinase with thrombospondin motifs 12	0.981	landscape →