Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 10/20 | 0.35 |
| ▸ | BRD4 | O60885 | 9/20 | 0.35 |
| ▸ | EP300 | Q09472 | 7/20 | 0.35 |
| ▸ | DDX3X | O00571 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17872100 | 0.75 | CDK7 (0.52) | MAPK1SRC | |
| SCHEMBL20741173 | 0.72 | CDK7 (0.61) | MAPK1SRC | |
| SCHEMBL17872104 | 0.72 | CDK7 (0.61) | MAPK1SRC | |
| SCHEMBL23260770 | 0.70 | C5AR1 (0.36) | CREBBPBRD4EP300 | |
| SCHEMBL19305457 | 0.63 | — | — | |
| Acetic Acid SCHEMBL5914600 | 0.62 | MAPT (0.78) | KDM4EMEN1LMNAGAAMAPT | |
| SCHEMBL4167089 | 0.61 | MAPT (0.49) | KDM4EMEN1LMNAGAAMAPT | |
| SCHEMBL2127990 | 0.59 | MAPT (0.86) | KDM4EMEN1LMNAGAAMAPT | |
| SCHEMBL1415666 | 0.58 | ALDH1A1 (0.60) | KDM4EMEN1LMNAGAAMAPT | |
| SCHEMBL6324644 | 0.58 | DHODH (0.72) | MEN1LMNAGAAMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3236959-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Dana Farber Cancer Institute, Inc. (US) | 2017-11-01 | — | — | EP | disclosed |
| WO-2016105528-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-06-30 | — | — | WO | disclosed |