Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 2/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17872111 | 0.87 | KMT2A (0.40) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL17872158 | 0.86 | KMT2A (0.43) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL17872163 | 0.82 | NTRK1 (0.47) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL17872084 | 0.80 | KIF11 (0.37) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL29574061 | 0.80 | CDK7 (0.46) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL17872086 | 0.77 | MAPT (0.40) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL17872165 | 0.74 | C5AR1 (0.38) | MKNK1C5AR1 | |
| SCHEMBL17872129 | 0.74 | KMT2A (0.43) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL17872102 | 0.74 | KMT2A (0.44) | MAPTALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL23260770 | 0.72 | C5AR1 (0.36) | SMN1; SMN2BRD4MKNK1C5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3236959-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | Dana Farber Cancer Institute, Inc. (US) | 2017-11-01 | — | — | EP | disclosed |
| WO-2016105528-A2 | INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2016-06-30 | — | — | WO | disclosed |