SCHEMBL17874015

SCHEMBL17874015

COC(=O)c1onc(-c2ccccc2)c1F

nearest known ligand 0.71

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 3/20 0.58
SMN1; SMN2 Q16637 1/20 0.50
LMNA P02545 2/20 0.48
POLB P06746 1/20 0.48
GABRA5 P31644 4/20 0.47
GABRA1 P14867 1/20 0.47
GABRG2 P18507 1/20 0.47
GABRB3 P28472 1/20 0.47
GABRA3 P34903 1/20 0.47
ALDH1A1 P00352 4/20 0.47
MEN1 O00255 1/20 0.43
GAA P10253 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12000493 0.83 PTGS1 (0.60) PTGS1SMN1; SMN2LMNAPOLBGABRA5
SCHEMBL2568217 0.83 PTGS1 (0.73) PTGS1SMN1; SMN2LMNAPOLBGABRA5
SCHEMBL17873985 0.82 KMT2A (0.45) PTGS1SMN1; SMN2LMNAALDH1A1MEN1
SCHEMBL2570531 0.82 PTGS1 (0.67) PTGS1SMN1; SMN2LMNAPOLBALDH1A1
SCHEMBL1805305 0.81 PTGS1 (0.55) PTGS1SMN1; SMN2LMNAPOLBGABRA5
SCHEMBL2570844 0.81 PTGS1 (0.55) PTGS1SMN1; SMN2LMNAPOLBGABRA5
SCHEMBL2565750 0.79 PTGS1 (0.68) PTGS1SMN1; SMN2LMNAPOLBGABRA5
SCHEMBL13349506 0.79 PTGS1 (0.56) PTGS1SMN1; SMN2LMNAPOLBGABRA5
SCHEMBL2565828 0.79 PTGS1 (0.56) PTGS1SMN1; SMN2LMNAPOLBGABRA5
SCHEMBL2570798 0.79 PTGS1 (0.71) PTGS1SMN1; SMN2LMNAPOLBGABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240139158-A1 METHODS OF TREATING PULMONARY DISEASES AND DISORDERS PROTEOSTASIS THERAPEUTICS INC (US) 2024-05-02 US disclosed
EP-3237411-B1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS INC (US) 2023-06-07 EP disclosed
EP-3237411-B1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS INC (US) 2023-06-07 EP disclosed
US-20220175735-A1 METHODS OF TREATING PULMONARY DISEASES AND DISORDERS PROTEOSTASIS THERAPEUTICS INC (US) 2022-06-09 US disclosed
US-20220175735-A1 METHODS OF TREATING PULMONARY DISEASES AND DISORDERS PROTEOSTASIS THERAPEUTICS INC (US) 2022-06-09 US disclosed
CN-107207487-B Compounds, compositions and methods for increasing CFTR activity 蛋白质平衡治疗股份有限公司 2021-12-28 CN disclosed
US-11083709-B2 Compounds, compositions, and methods of increasing CFTR activity PROTEOSTASIS THERAPEUTICS, INC. (US) 2021-08-10 US disclosed
US-11083709-B2 Compounds, compositions, and methods of increasing CFTR activity PROTEOSTASIS THERAPEUTICS, INC. (US) 2021-08-10 US disclosed
US-20200360348-A1 COMPOUNDS, COMPOSITIONS, AND METHODS OF INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. 2020-11-19 US disclosed
US-20200360348-A1 COMPOUNDS, COMPOSITIONS, AND METHODS OF INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. 2020-11-19 US disclosed
EP-3325474-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY Proteostasis Therapeutics, Inc. (US) 2018-05-30 EP disclosed
US-20170369480-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. 2017-12-28 US disclosed
US-20170369480-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. 2017-12-28 US disclosed
EP-3237411-A2 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY Proteostasis Therapeutics, Inc. (US) 2017-11-01 EP disclosed
WO-2017112853-A1 METHODS OF TREATING PULMONARY DISEASES AND DISORDERS PROTEOSTASIS THERAPEUTICS, INC. (US) 2017-06-29 WO disclosed
WO-2017112853-A1 METHODS OF TREATING PULMONARY DISEASES AND DISORDERS PROTEOSTASIS THERAPEUTICS, INC. (US) 2017-06-29 WO disclosed
WO-2017019589-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. (US) 2017-02-02 WO disclosed
WO-2017019589-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. (US) 2017-02-02 WO disclosed
WO-2016105485-A2 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. (US) 2016-06-30 WO disclosed
WO-2016105485-A2 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY PROTEOSTASIS THERAPEUTICS, INC. (US) 2016-06-30 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240139158-A1 METHODS OF TREATING PULMONARY DISEASES AND DISORDERS SMPD1, ELANE, SMPD2 PTGS1 261/4885SMN1; SMN2 1913/4885LMNA 3043/4885
US-20200360348-A1 COMPOUNDS, COMPOSITIONS, AND METHODS OF INCREASING CFTR ACTIVITY CFTR, ABCB4, SCNN1B PTGS1 1492/4885SMN1; SMN2 3701/4885LMNA 2454/4885
US-20170369480-A1 COMPOUNDS, COMPOSITIONS, AND METHODS FOR INCREASING CFTR ACTIVITY CFTR, SCNN1B, SCNN1G PTGS1 2402/4885SMN1; SMN2 4744/4885LMNA 2025/4885
US-11083709-B2 Compounds, compositions, and methods of increasing CFTR activity CFTR, ABCB4, SCNN1B PTGS1 1492/4885SMN1; SMN2 3701/4885LMNA 2454/4885
US-20220175735-A1 METHODS OF TREATING PULMONARY DISEASES AND DISORDERS SMPD1, ELANE, SMPD2 PTGS1 261/4885SMN1; SMN2 1913/4885LMNA 3043/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.