ABCB4 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Bms-986020 (SCHEMBL14590)	1.00	1/20
Bms-986020 (SCHEMBL343068)	1.00	1/20
Bms-986020 (SCHEMBL344742)	1.00	1/20
SCHEMBL343858	0.94	1/20
SCHEMBL343859	0.94	1/20
SCHEMBL343864	0.93	1/20
SCHEMBL343865	0.93	1/20
SCHEMBL344394	0.88	1/20
SCHEMBL344395	0.88	1/20
SCHEMBL1325788	0.86	1/20
SCHEMBL1325790	0.86	1/20
SCHEMBL343802	0.85	1/20
SCHEMBL344195	0.85	1/20
SCHEMBL344196	0.85	1/20
SCHEMBL343993	0.84	1/20
SCHEMBL343106	0.83	1/20
SCHEMBL343107	0.83	1/20
SCHEMBL343788	0.82	1/20
SCHEMBL8005	0.82	1/20
SCHEMBL8006	0.82	1/20

Clinical trials — most relevant to ABCB4 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Effects of Pioglitazone on High-density Lipoprotein (HDL) Function in Persons With Diabetes	PHASE3	COMPLETED
Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized)	PHASE3	UNKNOWN
Aerosol Combination Therapy of All-trans Retinoic Acid and Isotretinoin as A Novel Treatment for Inducing Neutralizing Antibodies in COVID -19 Infected Patients Better Than Vaccine : An Innovative Treatment	PHASE2	UNKNOWN
Tolerability of Enteral NAC in Infants	PHASE1	NOT_YET_RECRUITING
Utilizing Non-Invasive Fibroscan® Technology to Identify Genetic Markers for Fatty Liver Progression	nan	COMPLETED
Bile Acids Metabolism and Genetic Mutation Profile in the Intrahepatic Cholestasis of Pregnacy in Indian Population	nan	RECRUITING
Progressive Familial Intrahepatic Cholestasis in Indian Children - Establishing an Indian PFIC Registry	nan	UNKNOWN
ABCB4 Gene Mutations in Intrahepatic Cholestasis of Pregnancy and Controls	nan	COMPLETED
High-Density Lipoprotein (HDL) Treatment Study	nan	COMPLETED
Osmotic Fragility in Red Blood Cells of Pediatric Patients With Cholestatic Liver Disease	nan	ACTIVE_NOT_RECRUITING
Genetic Polymorphisms of ABCB11 and ABCB4 in Women With Intrahepatic Cholestasis of Pregnancy (ICP) and in Their First Degree Relatives	nan	UNKNOWN
Genetic and Metabolism of Post-prandial HDL Particles	nan	COMPLETED
Multidrug Resistance Genes in Patients With Acute Myeloid Leukemia	nan	ACTIVE_NOT_RECRUITING
The Metabolic Profile in Intrahepatic Cholestasis of Pregnancy and Diabetes Mellitus	nan	COMPLETED
Function and Imaging Assessments for G1961E-associated Stargardt Disease	nan	ACTIVE_NOT_RECRUITING
Coproporphyrine Isomers and Methotrexate Elimination	nan	COMPLETED
Gastrostomy-Biliary Diversion: Innovative Management for Bile Canalicular Transport Disorders	nan	UNKNOWN
Apolipoprotein A-I Gene Polymorphism and Atherosclerosis	nan	COMPLETED
Genetic Epidemiology of Coronary Heart Disease	nan	COMPLETED
An Observational Study in Children and Adults With Stargardt Disease	nan	ACTIVE_NOT_RECRUITING
The Association of SAA With Apolipoprotein B Affects Cardiovascular Risk	nan	COMPLETED
The Genetic, Protein, and Lipid Basis of Variation in Cholesterol Efflux	nan	COMPLETED
Bile Acid Effects in Fetal Arrhythmia Study	nan	UNKNOWN
The Effect of Dietary Sitosterol on Blood Sugar and Cholesterol	nan	COMPLETED
Human Lipoprotein Pathophysiology - Subproject: Genetics of Familial Combined Hyperlipidemia	nan	COMPLETED
ABCA4-associated Disease in Childhood and Adolescence - a Phenotype Study	nan	COMPLETED
Evaluation of Lipoproteins	nan	COMPLETED
HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism	nan	ACTIVE_NOT_RECRUITING
Genetic Regulation of Surfactant Deficiency	nan	COMPLETED
Study of Inborn Errors of Cholesterol Synthesis and Related Disorders	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ABCB4 binder may also engage these)

Protein	Name	Similarity
P21440	—	1.000	P21440 →
P21448	—	1.000	P21448 →
Q08201	—	1.000	Q08201 →
P23174	—	1.000	P23174 →
Q9M0M2	—	1.000	Q9M0M2 →
Q9QY30	—	1.000	Q9QY30 →
P06795	—	1.000	P06795 →
P21449	—	1.000	P21449 →
Q9N0V3	—	1.000	Q9N0V3 →
P21447	—	1.000	P21447 →
Q9FWX7	—	0.999	Q9FWX7 →
Q9SYI2	—	0.999	Q9SYI2 →
ABCB1	ATP-dependent translocase ABCB1	0.997	landscape →
P43245	—	0.996	P43245 →
O80725	—	0.996	O80725 →
Q9M1Q9	—	0.996	Q9M1Q9 →
B8K1W2	—	0.993	B8K1W2 →
Q9C7F8	—	0.993	Q9C7F8 →
Q9FHF1	—	0.993	Q9FHF1 →
Q8LPK2	—	0.992	Q8LPK2 →
Q9SYI3	—	0.991	Q9SYI3 →
Q9C7F2	—	0.991	Q9C7F2 →
Q9LJX0	—	0.990	Q9LJX0 →
P34712	—	0.990	P34712 →
Q9FWX8	—	0.990	Q9FWX8 →
A0A8B0M670	—	0.990	A0A8B0M670 →
Q9ZR72	—	0.989	Q9ZR72 →
Q9LHD1	—	0.989	Q9LHD1 →
ABCB11	Bile salt export pump	0.989	landscape →
B5X0E4	—	0.989	B5X0E4 →