Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.52 |
| ▸ | FAAH | O00519 | 14/20 | 0.35 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15328651 | 0.95 | PRKDC (0.53) | PRKDCFAAHSLC40A1KDM4EALDH1A1 | |
| SCHEMBL16653844 | 0.95 | PRKDC (0.53) | PRKDCFAAHSLC40A1KDM4EALDH1A1 | |
| SCHEMBL29392854 | 0.95 | PRKDC (0.53) | PRKDCFAAHSLC40A1KDM4EALDH1A1 | |
| SCHEMBL17634671 | 0.93 | PRKDC (0.60) | PRKDCFAAHSLC40A1KDM4EALDH1A1 | |
| SCHEMBL17874734 | 0.91 | PRKDC (0.57) | PRKDCFAAHSLC40A1KDM4EALDH1A1 | |
| SCHEMBL17874765 | 0.90 | PRKDC (0.55) | PRKDCFAAHKDM4EALDH1A1CYP1A2 | |
| SCHEMBL17874686 | 0.89 | PRKDC (0.54) | PRKDCFAAHSLC40A1KDM4EAURKA | |
| SCHEMBL17634601 | 0.89 | PRKDC (0.52) | PRKDCFAAHSLC40A1KDM4EALDH1A1 | |
| SCHEMBL15328700 | 0.87 | PRKDC (0.63) | PRKDCFAAHSLC40A1KDM4EALDH1A1 | |
| SCHEMBL16654055 | 0.87 | PRKDC (0.63) | PRKDCFAAHSLC40A1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376448-B2 | DNA-PK inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-06-28 | — | — | US | disclosed |