Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 6/20 | 0.37 |
| ▸ | AURKA | O14965 | 5/20 | 0.37 |
| ▸ | FAAH | O00519 | 7/20 | 0.36 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.36 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17874765 | 0.92 | PRKDC (0.55) | PRKDCKDM4ERPS6KB1AURKAFAAH | |
| SCHEMBL17634672 | 0.91 | PRKDC (0.64) | PRKDCL3MBTL1KDM4ERPS6KB1AURKA | |
| SCHEMBL29392854 | 0.91 | PRKDC (0.53) | PRKDCKDM4ERPS6KB1AURKAFAAH | |
| SCHEMBL16653844 | 0.91 | PRKDC (0.53) | PRKDCKDM4ERPS6KB1AURKAFAAH | |
| SCHEMBL15328651 | 0.91 | PRKDC (0.53) | PRKDCKDM4ERPS6KB1AURKAFAAH | |
| SCHEMBL17874684 | 0.89 | PRKDC (0.52) | PRKDCKDM4ERPS6KB1AURKAFAAH | |
| SCHEMBL17634566 | 0.87 | PRKDC (0.55) | PRKDCL3MBTL1KDM4ERPS6KB1AURKA | |
| SCHEMBL17874734 | 0.87 | PRKDC (0.57) | PRKDCKDM4ERPS6KB1AURKAFAAH | |
| SCHEMBL21155543 | 0.85 | PRKDC (0.50) | PRKDCL3MBTL1KDM4ERPS6KB1AURKA | |
| SCHEMBL19819867 | 0.84 | PRKDC (0.49) | PRKDCL3MBTL1KDM4ERPS6KB1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376448-B2 | DNA-PK inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-06-28 | — | — | US | disclosed |