Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.47 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 9/20 | 0.33 |
| ▸ | JAK1 | P23458 | 9/20 | 0.33 |
| ▸ | JAK2 | O60674 | 8/20 | 0.33 |
| ▸ | TYK2 | P29597 | 8/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17874796 | 0.94 | PRKDC (0.46) | PRKDCTDO2JAK3JAK1JAK2 | |
| SCHEMBL17874739 | 0.93 | PRKDC (0.48) | PRKDCJAK3SLC40A1 | |
| SCHEMBL19905467 | 0.93 | PRKDC (0.48) | PRKDCJAK3SLC40A1 | |
| SCHEMBL17874688 | 0.93 | PRKDC (0.52) | PRKDCJAK3SLC40A1DYRK1A | |
| SCHEMBL15473087 | 0.93 | PRKDC (0.46) | PRKDCMAPK10IRAK4DYRK1AWNT1 | |
| SCHEMBL17874766 | 0.93 | PRKDC (0.46) | PRKDCMAPK10IRAK4JAK3JAK1 | |
| SCHEMBL17874741 | 0.93 | PRKDC (0.46) | PRKDCMAPK10IRAK4DYRK1AWNT1 | |
| SCHEMBL19905456 | 0.93 | PRKDC (0.46) | PRKDCMAPK10IRAK4JAK3JAK1 | |
| SCHEMBL15473075 | 0.93 | PRKDC (0.46) | PRKDCMAPK10IRAK4JAK3JAK1 | |
| SCHEMBL17874787 | 0.89 | PRKDC (0.48) | PRKDCSLC40A1DYRK1AWNT1TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9376448-B2 | DNA-PK inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-06-28 | — | — | US | disclosed |