Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.36 |
| ▸ | CDK2 | P24941 | 6/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | SLC40A1 | Q9NP59 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17874739 | 1.00 | PRKDC (0.48) | PRKDCCCNA2CDK2CCNA1HDAC1 | |
| SCHEMBL17874688 | 0.94 | PRKDC (0.52) | PRKDCCDK2SLC40A1PAK4GSK3B | |
| SCHEMBL17634663 | 0.94 | PRKDC (0.47) | PRKDCPRMT5WDR77GSK3B | |
| SCHEMBL17874789 | 0.93 | PRKDC (0.47) | PRKDCSLC40A1JAK3 | |
| SCHEMBL17874741 | 0.91 | PRKDC (0.46) | PRKDCLCKMAPK14MAPK1 | |
| SCHEMBL15473087 | 0.91 | PRKDC (0.46) | PRKDCLCKMAPK14MAPK1 | |
| SCHEMBL17874766 | 0.91 | PRKDC (0.46) | PRKDCPRMT5WDR77SLC40A1GSK3B | |
| SCHEMBL15473075 | 0.91 | PRKDC (0.46) | PRKDCPRMT5WDR77GSK3BJAK3 | |
| SCHEMBL19905456 | 0.91 | PRKDC (0.46) | PRKDCPRMT5WDR77GSK3BJAK3 | |
| SCHEMBL17874720 | 0.89 | PRKDC (0.49) | PRKDCPRMT5WDR77SLC40A1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057959-B1 | DNA-PK INHIBITORS | VERTEX PHARMA (US) | 2018-02-28 | — | — | EP | disclosed |