Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANO1 | Q5XXA6 | 12/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14882576 | 0.87 | ANO1 (0.43) | ANO1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL14882688 | 0.87 | KDM4E (0.53) | ANO1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL14876376 | 0.86 | ANO1 (0.42) | ANO1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL14876429 | 0.86 | KDM4E (0.52) | ANO1KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL14882670 | 0.81 | ANO1 (0.49) | ANO1HDAC1GRM4 | |
| SCHEMBL18135096 | 0.80 | TSHR (0.46) | ANO1GRM4TSHR | |
| Hydrochloric Acid SCHEMBL14875986 | 0.80 | ANO1 (0.48) | ANO1HDAC1GRM4 | |
| SCHEMBL14882681 | 0.78 | HDAC6 (0.49) | ALDH1A1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL14882770 | 0.78 | ANO1 (0.50) | ANO1ALDH1A1HDAC3HDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL14876094 | 0.77 | HDAC6 (0.48) | ALDH1A1HDAC3HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794616-B1 | PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE | HOFFMANN LA ROCHE (CH) | 2016-06-29 | — | — | EP | disclosed |