Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 5/20 | 0.45 |
| ▸ | ANO1 | Q5XXA6 | 10/20 | 0.42 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.42 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14882688 | 0.87 | KDM4E (0.53) | TSHRGRM4ANO1 | |
| Hydrochloric Acid SCHEMBL14876429 | 0.86 | KDM4E (0.52) | TSHRGRM4ANO1 | |
| SCHEMBL14882735 | 0.85 | ALDH1A1 (0.52) | GRM4ANO1HDAC8 | |
| Hydrochloric Acid SCHEMBL14876192 | 0.84 | ALDH1A1 (0.51) | GRM4ANO1HDAC8 | |
| SCHEMBL14882576 | 0.83 | ANO1 (0.43) | TSHRGRM4ANO1 | |
| SCHEMBL14882742 | 0.82 | ANO1 (0.47) | ANO1HDAC8 | |
| Hydrochloric Acid SCHEMBL14876376 | 0.82 | ANO1 (0.42) | TSHRGRM4ANO1 | |
| SCHEMBL14882770 | 0.82 | ANO1 (0.50) | GRM4ANO1HDAC8 | |
| Hydrochloric Acid SCHEMBL14875722 | 0.81 | ANO1 (0.47) | ANO1HDAC8 | |
| Hydrochloric Acid SCHEMBL14875798 | 0.81 | ANO1 (0.49) | GRM4ANO1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160297763-A1 | Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease | F. HOFFMANN-LA ROCHE LTD (CH) | 2016-10-13 | — | — | US | disclosed |
| US-20160297763-A1 | Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease | F. HOFFMANN-LA ROCHE LTD (CH) | 2016-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297763-A1 | Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease | ALAD, CYP27A1, FAH | TSHR 2708/4885GRM4 3143/4885ANO1 4446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.